Evidence for genetic variability in venous responsiveness

Z. Vajo, B. Székács, W. Dachman

Research output: Article


Alterations in adrenergic mediated vascular responsiveness and glucose metabolism have been implicated in the pathogenesis of essential hypertension. We sought for a human model to study possible interactions between the two pathogenetical factors. In a group of Latin-Americans there is a predominance of diabetes mellitus, impaired glucose tolerance and obesity, while the rate of hypertension is unexpectedly low (lower than in the normal population). Here we demonstrate attenuated alpha] adrenergic mediated vasoconstriction in the above group, suggesting a possible protective mechanism against the development hypertension.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalActa physiologica Hungarica
Issue number4
Publication statusPublished - dec. 1 1996

ASJC Scopus subject areas

  • Physiology (medical)

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