Túlélés kevert kötószöveti betegségben (MCTD).

E. Bodolay, J. Gaál, Judit Végh, P. Soltész, Péter Szodoray, Gabriella Lakos, Z. Nemes, B. Dezső, G. Szegedi

Research output: Article

9 Citations (Scopus)

Abstract

INTRODUCTION: 179 patients with mixed connective tissue disease (MCTD) were follow-up, and the cause of death was analyzed in 12 died patients. PATIENTS AND METHODS: The survival of 179 patients with MCTD was evaluated by using Kaplan-Meier's method. Clinically and immunological data of the patients were analyzed between 1 and 25 years follow-up period (mean: 13.1 +/- 5.5 years). RESULTS: The five-year survival rate was 96.4%, 10-year survival rate was 93.9%, and the 15-year survival rate was 89.6%. The cause of death was pulmonary hypertension in 5 patients, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in 3 cases, infection in 3 cases (hepatitis C virus induced hepatic coma in 2 patients, Staphylococcus sepsis in one patient), and on one patient myocarditis. The pulmonary hypertension was the most serious prognostic factor. CONCLUSION: In patients with MCTD the pulmonary hypertension with endothelial cells proliferation and microangiopathy developed very quickly, and there was progressive and therapy resistant statement. The secondary virus and bacterial infections may develop in the patients who were followed-up the long term period. Their survival rate was better than the data in the literature. This fact may cause genetic-demographic factors, and the sequential follow-up of the patients.

Original languageHungarian
Pages (from-to)2543-2548
Number of pages6
JournalOrvosi Hetilap
Volume143
Issue number45
Publication statusPublished - nov. 10 2002

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Mixed Connective Tissue Disease
Survival
Survival Rate
Pulmonary Hypertension
Cause of Death
Thrombotic Thrombocytopenic Purpura
Hemolytic-Uremic Syndrome
Hepatic Encephalopathy
Myocarditis
Virus Diseases
Coinfection
Staphylococcus
Bacterial Infections
Hepacivirus
Sepsis
Endothelial Cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Túlélés kevert kötószöveti betegségben (MCTD). / Bodolay, E.; Gaál, J.; Végh, Judit; Soltész, P.; Szodoray, Péter; Lakos, Gabriella; Nemes, Z.; Dezső, B.; Szegedi, G.

In: Orvosi Hetilap, Vol. 143, No. 45, 10.11.2002, p. 2543-2548.

Research output: Article

Bodolay E, Gaál J, Végh J, Soltész P, Szodoray P, Lakos G et al. Túlélés kevert kötószöveti betegségben (MCTD). Orvosi Hetilap. 2002 nov. 10;143(45):2543-2548.
Bodolay, E. ; Gaál, J. ; Végh, Judit ; Soltész, P. ; Szodoray, Péter ; Lakos, Gabriella ; Nemes, Z. ; Dezső, B. ; Szegedi, G. / Túlélés kevert kötószöveti betegségben (MCTD). In: Orvosi Hetilap. 2002 ; Vol. 143, No. 45. pp. 2543-2548.
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AU - Gaál, J.

AU - Végh, Judit

AU - Soltész, P.

AU - Szodoray, Péter

AU - Lakos, Gabriella

AU - Nemes, Z.

AU - Dezső, B.

AU - Szegedi, G.

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