Equilibrium and structural studies on transition metal complexes of amino acid derivatives containing the bis(pyridin-2-yl)methyl residue

K. Ősz, K. Várnagy, I. Sóvágó, L. Lennert, H. Süli-Vargha, D. Sanna, G. Micera

Research output: Article

13 Citations (Scopus)

Abstract

The stoichiometries, stability constants and structures of the complexes formed in the reaction of copper(II), nickel(II) and zinc(II) ions and N-glycylbis(pyridin-2-yl)methylamine (Gly-BPMA) and N-histidylbis(pyridin-2-yl) methylamine (His-BPMA) ligands have been determined by potentiometric, UV-VIS and EPR spectroscopic methods. The formation of four-coordinate 1 : 1 copper(II) complexes and octahedral mono and bis(ligand) nickel(II) and zinc(II) complexes was detected. The bis(pyridin-2-yl)methyl moiety is the main binding site in acidic media, while deprotonation and coordination of the amide nitrogen take place in the physiological pH range. The stability of the complexes of the bis(pyridin-2-yl)methyl ligands is lower than that of analogous bis(imidazol-2-yl)methyl compounds. The weaker metal binding ability of the ligands containing the bis(pyridin-2-yl)methyl group is also reflected in the fact that, in contrast with analogous bis(imidazol-2-yl)methyl ligands, the non-coordinated pyridine nitrogens cannot act as a bridge-forming polymeric species.

Original languageEnglish
Pages (from-to)700-706
Number of pages7
JournalNew Journal of Chemistry
Volume25
Issue number5
DOIs
Publication statusPublished - 2001

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Coordination Complexes
Metal complexes
Transition metals
Amino acids
Ligands
Derivatives
Amino Acids
Nickel
Zinc
Copper
Nitrogen
Deprotonation
Binding sites
Amides
Stoichiometry
Pyridine
Paramagnetic resonance
Metals
Binding Sites
Ions

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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title = "Equilibrium and structural studies on transition metal complexes of amino acid derivatives containing the bis(pyridin-2-yl)methyl residue",
abstract = "The stoichiometries, stability constants and structures of the complexes formed in the reaction of copper(II), nickel(II) and zinc(II) ions and N-glycylbis(pyridin-2-yl)methylamine (Gly-BPMA) and N-histidylbis(pyridin-2-yl) methylamine (His-BPMA) ligands have been determined by potentiometric, UV-VIS and EPR spectroscopic methods. The formation of four-coordinate 1 : 1 copper(II) complexes and octahedral mono and bis(ligand) nickel(II) and zinc(II) complexes was detected. The bis(pyridin-2-yl)methyl moiety is the main binding site in acidic media, while deprotonation and coordination of the amide nitrogen take place in the physiological pH range. The stability of the complexes of the bis(pyridin-2-yl)methyl ligands is lower than that of analogous bis(imidazol-2-yl)methyl compounds. The weaker metal binding ability of the ligands containing the bis(pyridin-2-yl)methyl group is also reflected in the fact that, in contrast with analogous bis(imidazol-2-yl)methyl ligands, the non-coordinated pyridine nitrogens cannot act as a bridge-forming polymeric species.",
author = "K. Ősz and K. V{\'a}rnagy and I. S{\'o}v{\'a}g{\'o} and L. Lennert and H. S{\"u}li-Vargha and D. Sanna and G. Micera",
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TY - JOUR

T1 - Equilibrium and structural studies on transition metal complexes of amino acid derivatives containing the bis(pyridin-2-yl)methyl residue

AU - Ősz, K.

AU - Várnagy, K.

AU - Sóvágó, I.

AU - Lennert, L.

AU - Süli-Vargha, H.

AU - Sanna, D.

AU - Micera, G.

PY - 2001

Y1 - 2001

N2 - The stoichiometries, stability constants and structures of the complexes formed in the reaction of copper(II), nickel(II) and zinc(II) ions and N-glycylbis(pyridin-2-yl)methylamine (Gly-BPMA) and N-histidylbis(pyridin-2-yl) methylamine (His-BPMA) ligands have been determined by potentiometric, UV-VIS and EPR spectroscopic methods. The formation of four-coordinate 1 : 1 copper(II) complexes and octahedral mono and bis(ligand) nickel(II) and zinc(II) complexes was detected. The bis(pyridin-2-yl)methyl moiety is the main binding site in acidic media, while deprotonation and coordination of the amide nitrogen take place in the physiological pH range. The stability of the complexes of the bis(pyridin-2-yl)methyl ligands is lower than that of analogous bis(imidazol-2-yl)methyl compounds. The weaker metal binding ability of the ligands containing the bis(pyridin-2-yl)methyl group is also reflected in the fact that, in contrast with analogous bis(imidazol-2-yl)methyl ligands, the non-coordinated pyridine nitrogens cannot act as a bridge-forming polymeric species.

AB - The stoichiometries, stability constants and structures of the complexes formed in the reaction of copper(II), nickel(II) and zinc(II) ions and N-glycylbis(pyridin-2-yl)methylamine (Gly-BPMA) and N-histidylbis(pyridin-2-yl) methylamine (His-BPMA) ligands have been determined by potentiometric, UV-VIS and EPR spectroscopic methods. The formation of four-coordinate 1 : 1 copper(II) complexes and octahedral mono and bis(ligand) nickel(II) and zinc(II) complexes was detected. The bis(pyridin-2-yl)methyl moiety is the main binding site in acidic media, while deprotonation and coordination of the amide nitrogen take place in the physiological pH range. The stability of the complexes of the bis(pyridin-2-yl)methyl ligands is lower than that of analogous bis(imidazol-2-yl)methyl compounds. The weaker metal binding ability of the ligands containing the bis(pyridin-2-yl)methyl group is also reflected in the fact that, in contrast with analogous bis(imidazol-2-yl)methyl ligands, the non-coordinated pyridine nitrogens cannot act as a bridge-forming polymeric species.

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DO - 10.1039/b010212l

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