Ten polycyclic derivatives related to ellipticine have been synthesised and tested for their intercalating, reverse transcriptase (RT) inhibitory and multidrug resistance efflux pump inhibitory properties. The intercalating activity and the RT inhibitory activity of the derivatives suggest that ellipticine analogues bind at an allosteric binding site on RT or that this inhibition could be controlled at the DNA level. The MDR efflux pump inhibitory activities of these derivatives, however, appears to be unrelated to the DNA binding ability.
|Number of pages||6|
|Journal||Archiv der Pharmazie|
|Publication status||Published - jan. 1 2001|
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery