Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CA1 of hippocampal slices was performed after (I) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-d-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 μm distant from stratum pyramidale. Axonal mitochondria containing Ca deposits were evently distributed in stratum radiatum. The total number of calcium containing-mitochondria was highest in long-term potentiated slices, and less in slices treated with APV; the lowest values were obtained with low-frequency stimulation.
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