Electrophysiological effects of EGIS-7229, a new antiarrhythmic agent, in isolated guinea pig papillary muscle

Csaba Pankucsi, Tamás Bányász, J. Magyar, Ildikó Gyönös, Anikó Kovâcs, G. Szénási, A. Varró, P. Nánási

Research output: Article

8 Citations (Scopus)

Abstract

1. The cellular electrophysiological effects of EGIS-7229, a novel antiarrhythmic agent, were studied in guinea pig papillary muscles with the use of conventional microelectrode techniques. 2. The drug had a concentration-dependent biphasic effect on action potential duration (APD). APD was significantly lengthened at low concentration (3 μmol/l), whereas it was shortened at concentrations higher than 10 μmol/l. 3. At concentrations higher than 10 μmol/l, the drug decreased the maximum velocity of action potential upstroke (V(max)), the force of contraction, and altered the restitution kinetics of APD. 4. The effect of EGIS-7229 on V(max) was frequency dependent; it was most prominent at short pacing cycle lengths (use dependent block). 5. On the basis of present results, EGIS-7229 appears to carry mixed class I and class III characteristics. Class III properties are present at low concentrations, whereas, at higher concentrations, class I actions may be predominant.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalGeneral Pharmacology
Volume29
Issue number2
DOIs
Publication statusPublished - aug. 1997

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Papillary Muscles
Action Potentials
Guinea Pigs
Microelectrodes
Pharmaceutical Preparations
EGIS 7229

ASJC Scopus subject areas

  • Pharmacology

Cite this

Electrophysiological effects of EGIS-7229, a new antiarrhythmic agent, in isolated guinea pig papillary muscle. / Pankucsi, Csaba; Bányász, Tamás; Magyar, J.; Gyönös, Ildikó; Kovâcs, Anikó; Szénási, G.; Varró, A.; Nánási, P.

In: General Pharmacology, Vol. 29, No. 2, 08.1997, p. 275-280.

Research output: Article

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