Electron microscopic characteristics of β2-microglobulin amyloid deposits in long-term hemodialysis

Miklós Bély, Pal Kapp, Tamás Szentjóbi Szabó, Tamás Lakatos, Ágnes Apáthy

Research output: Article

6 Citations (Scopus)

Abstract

The electron microscopic features of β2-microglobulin amyloid, deposited in the synovial membrane, are presented and discussed. The patient, a 69-year-old woman underwent chronic hemodialysis for 3 years. Because of constant pain and destructive arthropathy, endoprosthesis of the hip joints were implanted. Extra- and intracellular filamentous-fibrillar amyloid deposits have been demonstrated in ultrathin sections. The extracellular amyloid deposits showed a loose, filamentous or fibrillar structure at the periphery and a dense central core. The loose, filamentous structure may represent an early stage of fresh, newly deposited β2-microglobulin amyloid, while the condensed and fragmented amyloid filaments may be an advanced "mature" stage of amyloid deposition.

Original languageEnglish
Pages (from-to)483-491
Number of pages9
JournalUltrastructural Pathology
Volume29
Issue number6
DOIs
Publication statusPublished - nov. 1 2005

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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