Efficient synthesis of a novel estrone-talaromycin hybrid natural product

Lutz F. Tietze, Gyula Schneider, János Wölfling, Thomas Nöbel, Christian Wulff, Ingrid Schubert, Angela Rübeling

Research output: Article

46 Citations (Scopus)


Numerous pharmacologically interesting compounds are available by the synthesis of hybrid natural products. Thus, for instance, the estrone-talaromycin hybrid 2, which is synthesized in a few steps from the estrone derivative 1 by a sequence in which a hetero-Diels-Alder reaction is the key step, exhibits notable cytotoxic activity.

Original languageEnglish
Pages (from-to)2469-2470
Number of pages2
JournalAngewandte Chemie - International Edition
Issue number18
Publication statusPublished - okt. 2 1998

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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