Efficient and selective hydration of nitriles to amides in aqueous systems with Ru(II)-phosphaurotropine catalysts

Evelin Bolyog-Nagy, Antal Udvardy, Ferenc Joó, Ágnes Kathó

Research output: Article

27 Citations (Scopus)

Abstract

A simple and efficient synthesis of amides by selective hydration of aromatic and aliphatic nitriles is described. The catalysts are prepared in situ from easily available Ru-precursors and ligands using water as the solvent. The most active catalyst, is obtained from [RuCl2(dmso)4] and benzylated 1,3,5-triaza-7-phosphaadamantane. Of the 16 substrates examined, 92-99% conversions of 14 nitriles were achieved in one hour at reflux temperature.

Original languageEnglish
Pages (from-to)3615-3617
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number26
DOIs
Publication statusPublished - jún. 25 2014

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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