Efficacy of romiplostim in the treatment of chemotherapy induced thrombocytopenia (CIT) in a patient with mantle cell lymphoma

J. Demeter, Ildiko Istenes, Anikó Fodor, Melinda Paksi, Peter Dombi, Erika Valasinyószki, Judit Csomor, A. Matolcsy, Zsolt G. Nagy

Research output: Article

15 Citations (Scopus)

Abstract

Chemotherapy induced thrombopenia (CIT) is difficult to treat, as previous treatment options, including recombinant human thrombopoietin proved to be of limited efficacy. Here we report a case of a mantle cell lymphoma patient treated with intensive chemotherapy, who belongs to Yehova's witnesses and therefore did not accept platelet transfusions. At the time of severe thrombocytopenia (zero thrombocytes/ per mikroliter) and gastrointestinal bleeding, on day 13 following the start of hyperCVAD B chemotherapy, romiplostim treatment was given resulting in quick normalisation of the platelet count followed by thrombocytosis. Based on our observation in further studies modification of the dose and timing of romiplostim injection in CIT should be considered.

Original languageEnglish
Pages (from-to)141-143
Number of pages3
JournalPathology and Oncology Research
Volume17
Issue number1
DOIs
Publication statusPublished - márc. 2011

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Mantle-Cell Lymphoma
Thrombocytopenia
Drug Therapy
Thrombopoietin
Thrombocytosis
Platelet Transfusion
Therapeutics
Platelet Count
Blood Platelets
Observation
Hemorrhage
Injections
romiplostim

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Efficacy of romiplostim in the treatment of chemotherapy induced thrombocytopenia (CIT) in a patient with mantle cell lymphoma. / Demeter, J.; Istenes, Ildiko; Fodor, Anikó; Paksi, Melinda; Dombi, Peter; Valasinyószki, Erika; Csomor, Judit; Matolcsy, A.; Nagy, Zsolt G.

In: Pathology and Oncology Research, Vol. 17, No. 1, 03.2011, p. 141-143.

Research output: Article

Demeter, J. ; Istenes, Ildiko ; Fodor, Anikó ; Paksi, Melinda ; Dombi, Peter ; Valasinyószki, Erika ; Csomor, Judit ; Matolcsy, A. ; Nagy, Zsolt G. / Efficacy of romiplostim in the treatment of chemotherapy induced thrombocytopenia (CIT) in a patient with mantle cell lymphoma. In: Pathology and Oncology Research. 2011 ; Vol. 17, No. 1. pp. 141-143.
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