Az MNC+/10a jelu, Aujeszky-betegség elleni, élo vakcinatörzs hatékonysága sertésben

B. Lomniczi, Kelemen Mária

Research output: Article

Abstract

Groups of pigs free from Aujeszky-disease virus (ADV) antibodies were vaccinated once or twice with Aujeszky-vaccine Auphyl-plus that contains an attenuated strain MNC+/10a (15) with an oil/water emulsion adjuvant. Strain MNC+/10a is a genetically improved version of vaccine strain K/61 (6) whose impaired gC-function has been restored. MNC+/10a forms larger plaques in cell culture and induces more antibody in pigs even after a single injection as compared to strain K/ 61 (15). Two injections of Auphyl-plus separated by 3 weeks induced 10-30 fold antibody titres than one injection of the vaccine. Three weeks after the first or second injection pigs were challenged intranasally with 104 PFU of virulent strain NIA-3 in two separate experiments. Most unvaccinated animals showed severe respiratory and nervous signs after 4-6 days and the average daily weight gains were reduced to about -2.5% in the control groups. Altogether ten of the twelve control animals succumbed to the challenge infection. A single dose of the vaccine was sufficient to prevent disease but did not prevent mild (

Translated title of the contributionEfficacy of live Aujeszky-vaccine containing strain MNC+/10a in pigs
Original languageHungarian
Pages (from-to)515-522
Number of pages8
JournalMagyar Allatorvosok Lapja
Volume120
Issue number9
Publication statusPublished - 1998

Fingerprint

Swine
Vaccines
vaccines
injection
Injections
swine
antibodies
Antibodies
Suid Herpesvirus 1
Suid herpesvirus 1
Emulsions
adjuvants
Weight Gain
emulsions
animals
Oils
cell culture
Cell Culture Techniques
weight gain
Control Groups

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Az MNC+/10a jelu, Aujeszky-betegség elleni, élo vakcinatörzs hatékonysága sertésben. / Lomniczi, B.; Mária, Kelemen.

In: Magyar Allatorvosok Lapja, Vol. 120, No. 9, 1998, p. 515-522.

Research output: Article

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abstract = "Groups of pigs free from Aujeszky-disease virus (ADV) antibodies were vaccinated once or twice with Aujeszky-vaccine Auphyl-plus that contains an attenuated strain MNC+/10a (15) with an oil/water emulsion adjuvant. Strain MNC+/10a is a genetically improved version of vaccine strain K/61 (6) whose impaired gC-function has been restored. MNC+/10a forms larger plaques in cell culture and induces more antibody in pigs even after a single injection as compared to strain K/ 61 (15). Two injections of Auphyl-plus separated by 3 weeks induced 10-30 fold antibody titres than one injection of the vaccine. Three weeks after the first or second injection pigs were challenged intranasally with 104 PFU of virulent strain NIA-3 in two separate experiments. Most unvaccinated animals showed severe respiratory and nervous signs after 4-6 days and the average daily weight gains were reduced to about -2.5{\%} in the control groups. Altogether ten of the twelve control animals succumbed to the challenge infection. A single dose of the vaccine was sufficient to prevent disease but did not prevent mild (",
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