Renal effects of furosemide were examined during the first 2-4 days of life in preterm infants suffering from respiratory distress syndrome. Administration of the drug was followed by a 7-fold increase of diuresis. This latter was a result of both a rise in sodium excretion and glomerular filtration. The possible mechanism of furosemide-induced alteration in the glomerular filtration is discussed. Furosemide also altered the hydrogen-ion excretion: both the urinary bicarbonate, the titratable acidity and the ammonium excretion increased. There was a significant rise in the net acid excretion and hydrogen clearance too. It has been found that besides its diuretic effect furosemide might play a role in the renal hydrogen elimination.
|Number of pages||5|
|Journal||Monatsschrift fur Kinderheilkunde|
|Publication status||Published - jan. 1 1982|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health