Effects of cyclooxygenase inhibitors and PGI2 on the adrenergic contractions of isolated rabbit arteries

B. Malomvolgyi, P. Hadhazy, K. Magyar

Research output: Article

1 Citation (Scopus)

Abstract

The effect of three cyclooxygenase inhibitors (indomethacin, suprofen, meclofenamic acid) and PGI2 on the contractile responses to noradrenaline (NA) and to nerve stimulation (TNS) of strips of rabbit coeliac, pulmonary, ear, carotid and femoral arteries and the aorta were studied. The equipotent concentration (0.1 x EC50) of NA were calculated from dose-response curves. The stimulation parameters (Hz, duration) varied according to the responsiveness of the tissue. Both NA and TNS caused 7-23% of maximum response. In the presence of cyclooxygenase inhibitors (COI's) NA and TNS produced a significantly greater proportion (15-30%) of maximum contraction in coeliac, ear and pulmonary arteries. Contractions of the other 3 vessels were not infuenced by COI's. The inhibitory potency of PGI2 was determined on contractions produced by equipotent concentration (EC50) of NA. PGI2 was highly effective in coeliac arteries, it was less potent in pulmonary and ear arteries and had no effect on the responses of the other vessels.

Original languageEnglish
JournalBiomedica Biochimica Acta
Volume43
Issue number8-9
Publication statusPublished - 1984

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Cyclooxygenase Inhibitors
Epoprostenol
Adrenergic Agents
Norepinephrine
Arteries
Rabbits
Celiac Artery
Pulmonary Artery
Ear
Suprofen
Meclofenamic Acid
Femoral Artery
Carotid Arteries
Indomethacin
Abdomen
Aorta
Tissue

ASJC Scopus subject areas

  • Biochemistry

Cite this

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abstract = "The effect of three cyclooxygenase inhibitors (indomethacin, suprofen, meclofenamic acid) and PGI2 on the contractile responses to noradrenaline (NA) and to nerve stimulation (TNS) of strips of rabbit coeliac, pulmonary, ear, carotid and femoral arteries and the aorta were studied. The equipotent concentration (0.1 x EC50) of NA were calculated from dose-response curves. The stimulation parameters (Hz, duration) varied according to the responsiveness of the tissue. Both NA and TNS caused 7-23{\%} of maximum response. In the presence of cyclooxygenase inhibitors (COI's) NA and TNS produced a significantly greater proportion (15-30{\%}) of maximum contraction in coeliac, ear and pulmonary arteries. Contractions of the other 3 vessels were not infuenced by COI's. The inhibitory potency of PGI2 was determined on contractions produced by equipotent concentration (EC50) of NA. PGI2 was highly effective in coeliac arteries, it was less potent in pulmonary and ear arteries and had no effect on the responses of the other vessels.",
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T1 - Effects of cyclooxygenase inhibitors and PGI2 on the adrenergic contractions of isolated rabbit arteries

AU - Malomvolgyi, B.

AU - Hadhazy, P.

AU - Magyar, K.

PY - 1984

Y1 - 1984

N2 - The effect of three cyclooxygenase inhibitors (indomethacin, suprofen, meclofenamic acid) and PGI2 on the contractile responses to noradrenaline (NA) and to nerve stimulation (TNS) of strips of rabbit coeliac, pulmonary, ear, carotid and femoral arteries and the aorta were studied. The equipotent concentration (0.1 x EC50) of NA were calculated from dose-response curves. The stimulation parameters (Hz, duration) varied according to the responsiveness of the tissue. Both NA and TNS caused 7-23% of maximum response. In the presence of cyclooxygenase inhibitors (COI's) NA and TNS produced a significantly greater proportion (15-30%) of maximum contraction in coeliac, ear and pulmonary arteries. Contractions of the other 3 vessels were not infuenced by COI's. The inhibitory potency of PGI2 was determined on contractions produced by equipotent concentration (EC50) of NA. PGI2 was highly effective in coeliac arteries, it was less potent in pulmonary and ear arteries and had no effect on the responses of the other vessels.

AB - The effect of three cyclooxygenase inhibitors (indomethacin, suprofen, meclofenamic acid) and PGI2 on the contractile responses to noradrenaline (NA) and to nerve stimulation (TNS) of strips of rabbit coeliac, pulmonary, ear, carotid and femoral arteries and the aorta were studied. The equipotent concentration (0.1 x EC50) of NA were calculated from dose-response curves. The stimulation parameters (Hz, duration) varied according to the responsiveness of the tissue. Both NA and TNS caused 7-23% of maximum response. In the presence of cyclooxygenase inhibitors (COI's) NA and TNS produced a significantly greater proportion (15-30%) of maximum contraction in coeliac, ear and pulmonary arteries. Contractions of the other 3 vessels were not infuenced by COI's. The inhibitory potency of PGI2 was determined on contractions produced by equipotent concentration (EC50) of NA. PGI2 was highly effective in coeliac arteries, it was less potent in pulmonary and ear arteries and had no effect on the responses of the other vessels.

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