1. The effect of various chemotherapeutic drugs (BCM, Nitromin, TEM, Myleran, Colcemid, Teropterin, Honvan, cortisone) upon the production of metastases in animals has been studied. 2. It has been found that Teropterin, Honvan, and Myleran, do not essentially affect generalisation of intravenously-inoculated Guerin T108 rat carcinoma, or the survival time, and that Colcemid, like cortisone, exerts effects that are rather adverse than favourable. 3. Only the radiomimetic substances BCM, Nitromin, and TEM, have been observed to produce favourable effects; principally BCM, which inhibited generalisation of intravenously-inoculated tumours and the establishment of multiple metastases; moreover, when combined with cortisone in the treatment, it warded off the latter's tendency to intensify metastasis production; it also prolonged the survival time of the animals.
ASJC Scopus subject areas
- Cancer Research