The effect of dialysable human transfer factor on the intracellular cAMP and cGMP level of human mononuclear cells (more than 90% lymphocytes) was investigated. The transfer factor tested was found to exert biological activity both in vitro and in vivo. After addition of transfer factor to mononuclear cells, there was a rapid increase in the intracellular cAMP and cGMP levels followed by a decrease in the cAMP/cGMP ratio. This may represent the 'activated', state of cells. It seems likely that the biological effect of the transfer factor is connected with its action on the cyclic nucleotides, and its effect can be predicted by the technique described.
|Number of pages||5|
|Journal||Acta medica Academiae Scientiarum Hungaricae|
|Publication status||Published - jan. 1 1977|
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