Effect of the extent of thiolation and introduction of phosphorothioate internucleotide linkages on the anti-HIV activity of Suligovir [(s4dU)35]

András Horváth, Zoltán Beck, Thomas J. Bardos, Joseph A. Dunn, Janos Aradi

Research output: Article

4 Citations (Scopus)

Abstract

Suligovir is a 35-mer homo-oligonucleotide, containing exclusively 4-thio deoxyuridylate, proved to be a potent inhibitor of HIV entry. In this paper, we described the effect of extent of thiolation and the introduction of nuclease-resistant phosphorothioate linkages on the anti-HIV activity of Suligovir. We found that the decreased thiolated nucleotide content decreases the anti-HIV potency of the compound and the introduction of phosphorothioate linkages does not improve its antiviral activity.

Original languageEnglish
Pages (from-to)5321-5323
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number20
DOIs
Publication statusPublished - okt. 15 2006

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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