Effect of single-nucleotide polymorphisms on specific reproduction parameters in Hungarian Large White sows

Eszter Erika Balogh, György Gábor, Szilárd Bodó, László Rózsa, J. Rátky, A. Zsolnai, István Anton

Research output: Article

Abstract

The aim of this study was to reveal the effect of single-nucleotide polymorphisms (SNPs) on the total number of piglets born (TNB), the litter weight born alive (LWA), the number of piglets born dead (NBD), the average litter weight on the 21st day (M21D) and the interval between litters (IBL). Genotypes were determined on a high-density Illumina Porcine SNP 60K BeadChip. Data screening and data identification were performed by a multi-locus mixed-model. Statistical analyses were carried out to find associations between individual genotypes of 290 Hungarian Large White sows and the investigated reproduction parameters. According to the analysis outcome, three SNPs were identified to be associated with TNB. These loci are located on chromosomes 1, 6 and 13 (-log10P = 6.0, 7.86 and 6.22, the frequencies of their minor alleles, MAF, were 0.298, 0.299 and 0.364, respectively). Two loci showed considerable association (-log10P = 10.35 and 10.46) with LWA on chromosomes 5 and X, the MAF were 0.425 and 0.446, respectively. Seven loci were found to be associated with NBD. These loci are located on chromosomes 5, 6, 13, 14, 15, 16 and 18 (-log10P = 10.95, 5.43, 8.29, 6.72, 6.81, 5.90, and 5.15, respectively). One locus showed association (-log10P = 5.62) with M21D on chromosome 1 (the MAF was 0.461). Another locus was found to be associated with IBL on chromosome 8 (-log10P = 7.56; the MAF was 0.438). The above-mentioned loci provide a straightforward possibility to assist selection by molecular tools and, consequently, to improve the competitiveness of the Hungarian Large White (HLW) breed.

Original languageEnglish
Pages (from-to)256-273
Number of pages18
JournalActa veterinaria Hungarica
Volume67
Issue number2
DOIs
Publication statusPublished - jún. 1 2019

Fingerprint

Large White
single nucleotide polymorphism
Single Nucleotide Polymorphism
Reproduction
sows
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 1
Weights and Measures
loci
Genotype
litter weight
piglets
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 8
chromosomes
Swine
Alleles
litters (young animals)
genotype

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of single-nucleotide polymorphisms on specific reproduction parameters in Hungarian Large White sows. / Balogh, Eszter Erika; Gábor, György; Bodó, Szilárd; Rózsa, László; Rátky, J.; Zsolnai, A.; Anton, István.

In: Acta veterinaria Hungarica, Vol. 67, No. 2, 01.06.2019, p. 256-273.

Research output: Article

Balogh, Eszter Erika ; Gábor, György ; Bodó, Szilárd ; Rózsa, László ; Rátky, J. ; Zsolnai, A. ; Anton, István. / Effect of single-nucleotide polymorphisms on specific reproduction parameters in Hungarian Large White sows. In: Acta veterinaria Hungarica. 2019 ; Vol. 67, No. 2. pp. 256-273.
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AU - Rózsa, László

AU - Rátky, J.

AU - Zsolnai, A.

AU - Anton, István

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