Effect of rabbit κ-casein expression on the properties of milk from transgenic mice

László Hiripi, Mária Baranyi, László Szabó, Szabolcs Tóth, Marie Louise Fontaine, Eve Devinoy, Zsuzsanna Bösze

Research output: Article

11 Citations (Scopus)


Transgenic mice were produced carrying the coding region of the rabbit κ-casein gene linked to the upstream region of the rabbit whey acidic protein gene. Mice from the highest-expressing line produced 2·5 mg rabbit κ-casein/ml in their milk. The foreign protein was associated with the casein micelles and altered micelle size, though in the high-expressing line rabbit κ-casein also segregated into the whey fraction obtained after centrifuging the milk samples. Milk from transgenic mice had the same overall protein content as that from non-transgenic mice, except for the transgene product. However, litters fed with this transgenic mouse milk grew less well than litters given milk from non-transgenic mice. This reduction in growth was not related to changes in mammary gland structure or mammary cell morphology. Preliminary results indicated that milk from the transgenic mice had a higher viscosity.

Original languageEnglish
Pages (from-to)541-550
Number of pages10
JournalJournal of Dairy Research
Issue number4
Publication statusPublished - dec. 1 2000

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology

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