Effect of PACAP in central and peripheral nerve injuries

Andrea Tamas, Dora Reglodi, Orsolya Farkas, Erzsebet Kovesdi, Jozsef Pal, John T. Povlishock, Attila Schwarcz, Endre Czeiter, Zalan Szanto, Tamas Doczi, Andras Buki, Peter Bukovics

Research output: Review article

43 Citations (Scopus)

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) is a bioactive peptide with diverse effects in the nervous system. In addition to its more classic role as a neuromodulator, PACAP functions as a neurotrophic factor. Several neurotrophic factors have been shown to play an important role in the endogenous response following both cerebral ischemia and traumatic brain injury and to be effective when given exogenously. A number of studies have shown the neuroprotective effect of PACAP in different models of ischemia, neurodegenerative diseases and retinal degeneration. The aim of this review is to summarize the findings on the neuroprotective potential of PACAP in models of different traumatic nerve injuries. Expression of endogenous PACAP and its specific PAC1 receptor is elevated in different parts of the central and peripheral nervous system after traumatic injuries. Some experiments demonstrate the protective effect of exogenous PACAP treatment in different traumatic brain injury models, in facial nerve and optic nerve trauma. The upregulation of endogenous PACAP and its receptors and the protective effect of exogenous PACAP after different central and peripheral nerve injuries show the important function of PACAP in neuronal regeneration indicating that PACAP may also be a promising therapeutic agent in injuries of the nervous system.

Original languageEnglish
Pages (from-to)8430-8448
Number of pages19
JournalInternational journal of molecular sciences
Volume13
Issue number7
DOIs
Publication statusPublished - júl. 2012

    Fingerprint

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this