Effect of MSC on the immune response of mice

M. Hídvégi, E. Rásó, Rita Tömösközi Farkas, K. Lapis, B. Szende

Research output: Article

29 Citations (Scopus)

Abstract

The supposed immunostimulatory actions of MSC, a new fermented wheat germ extract standardized to its benzoquinone composition (trade name: AVEMAR) were studied examining blastic transformation of peripheral blood lymphocytes of mice treated with MSC. It was found that MSC significantly increased the degree of blastic transformation caused by Concanavalin A. Using the B10LP to C57Bl skin graft system, MSC (0.03 and 3.0 g kg-1 applied orally) acted in favour of restoring the immune function. On the other hand, 2,6-dimethoxy-p-benzoquinone (DMBQ), applied in equivalent doses (0.012 and 1.2 mg kg-1), did not shorten the rejection time of skin grafts. The immune restoring effect, as well as the blastic transformation enhancing potential of MSC may be exploited in various cases of decreased immune response. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalImmunopharmacology
Volume41
Issue number3
DOIs
Publication statusPublished - ápr. 1999

Fingerprint

Transplants
Skin
Concanavalin A
Names
Lymphocytes
2,6-dimethoxy-1,4-benzoquinone
benzoquinone
Avemar

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of MSC on the immune response of mice. / Hídvégi, M.; Rásó, E.; Farkas, Rita Tömösközi; Lapis, K.; Szende, B.

In: Immunopharmacology, Vol. 41, No. 3, 04.1999, p. 183-186.

Research output: Article

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AU - Szende, B.

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