Effect of intratracheal fibres exposure on the rat lung.

Zuzana Kováciková, Marta Hurbánková, Erzsébet Tátrai, Silvia Cerná

Research output: Article

Abstract

The changes in antioxidant status of rat lung after intratracheal instillation of stone-wool and glass fibres were studied. The animals were exposed to 2 or 8 mg of fibres for 4 or 16 weeks, the bronchoalveolar lavage was performed and the activity of superoxide dismutase, glutathione peroxidase and the total amount of glutathione was estimated both in tissue and in cell free fraction of bronchoalveolar lavage and the ascorbic acid was determined in lung tissue. The results showed the higher burden by stone-wool. Most changes were detected in groups exposed to higher dose of fibres for shorter time period, the most sensitive parameter was superoxide dismutase. The lung tissue was studied also by light microscopy and transmission electron microscopy.

Original languageEnglish
Pages (from-to)363-365
Number of pages3
JournalBiomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Volume149
Issue number2
DOIs
Publication statusPublished - dec. 2005

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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