Effect of human adenovirus on natural killer cell activity in mice.

Y. Mándi, G. Seprényi, R. Pusztai

Research output: Article


The influence of human adenovirus type 6 on the natural killer cell activity in mice has been investigated. The cytotoxic effect of splenic mononuclear cells of different mouse strains (Balb/c, CBA and BlO) against YAC-1 cells was estimated using a 51Cr release system assay. The effector cells responsible for cytotoxicity were identified by Percoll density gradient fractionation as LGL cells. A single intraperitoneal injection of the virus enhanced the natural killer activity in all three strains of mice. The cytotoxicity was enhanced 24 to 48 h after the virus injection, depending on the host strains, but it then decreased and the preinjection level was reached after 72 h. A good correlation was found between the augmented cytotoxicity and interferon induction.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalActa microbiologica Hungarica
Issue number4
Publication statusPublished - dec. 1 1985

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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