Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K+-channel, on ischaemia-reperfusion induced arrhythmias in rats

Ö Bozdogan, I. Leprán, J. Gy Papp

Research output: Article

5 Citations (Scopus)

Abstract

Glibenclamide or glimepiride pretreatment (5 mg/kg ip. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82% or 67% vs. 17% in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31%), while glimepiride still offered a significant protection (61%). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion.

Original languageEnglish
Pages (from-to)265-266
Number of pages2
JournalActa physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - dec. 1 1996

ASJC Scopus subject areas

  • Physiology (medical)

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