Glibenclamide or glimepiride pretreatment (5 mg/kg ip. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82% or 67% vs. 17% in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31%), while glimepiride still offered a significant protection (61%). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion.
|Number of pages||2|
|Journal||Acta physiologica Hungarica|
|Publication status||Published - dec. 1 1996|
ASJC Scopus subject areas
- Physiology (medical)