Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: A mendelian randomisation approach

Paul Brennan, Charles C. Hsu, Norman Moullan, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, David Zaridze, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Federica Gemignani, Amelie Chabrier, Janet Hall, Rayjean J. Hung, Paolo Boffetta, Federico Canzian

Research output: Article

109 Citations (Scopus)

Abstract

Whether consumption of cruciferous vegetables protects against lung cancer is unclear, largely because of potential confounding factors. We therefore studied the role of cruciferous vegetables in lung cancer after stratifying by GSTM1 and GSTT1 status, two genes implicated in the elimination of isothiocyanates, the likely chemopreventative compound. In 2141 cases and 2168 controls, weekly consumption of cruciferous vegetables protected against lung cancer in those who were GSTM1 null (odds ratio=0·67, 95% CI 0·49-0·91), GSTT1 null (0·63, 0·37-1·07), or both (0·28, 0·11-0·67). No protective effect was seen in people who were both GSTM1 and GSTT1 positive (0·88, 0·65- 1·21). Similar protective results were noted for consumption of cabbage and a combination of broccoli and brussels sprouts. These data provide strong evidence for a substantial protective effect of cruciferous vegetable consumption on lung cancer.

Original languageEnglish
Pages (from-to)1558-1560
Number of pages3
JournalLancet
Volume366
Issue number9496
DOIs
Publication statusPublished - okt. 29 2005

ASJC Scopus subject areas

  • Medicine(all)

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    Brennan, P., Hsu, C. C., Moullan, N., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Gemignani, F., Chabrier, A., Hall, J., Hung, R. J., Boffetta, P., & Canzian, F. (2005). Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: A mendelian randomisation approach. Lancet, 366(9496), 1558-1560. https://doi.org/10.1016/S0140-6736(05)67628-3