Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL)

Melinda Kovács, Gábor Tornyos, Zsolt Matics, Miklós Mézes, Krisztián Balogh, Veronika Rajli, Zsófia Bloch-Bodnár, Miklós Rusvai, Míra Mándoki, Sándor Cseh

Research output: Article

10 Citations (Scopus)

Abstract

T-2 toxin (T-2) was administered to adult Pannon White (n=10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2. mg/animal/day), and secondly mixed into the feed (0.33 and 0.66. mg/kg feed). In the first experiment 0.1. mg T-2 exposure resulted in temporary decrease in feed intake, slower increase in the gonadotropin-releasing hormone (GnRH) induced testosterone synthesis, slight centrolobular infiltration in the liver and a slight hyperplasia of the Leydig cells. In addition to the temporary feed refusal effect, 0.2. mg T-2 caused a temporary decrease in plasma albumin and urea concentrations, lesser glutathione peroxidase (GPx) activity in the seminal plasma, a greater (by 320%) ratio of spermatozoa with cytoplasmic droplets, slower increase in the GnRH-induced testosterone synthesis, centrolobular infiltration in the liver, slightly hyperaemic testes and increased proliferative activity of the Leydig cells. The two smaller doses applied in feed (0.33 and 0.66. mg/kg) did not cause any significant adverse effect, and no feed refusal was observed. According to these results the No Observed Adverse Effect Level (NOAEL) of T-2 for adult rabbit males was found to be <0.1. mg/animal/day (<0.02. mg/kg. b.w./day).

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalAnimal Reproduction Science
Volume137
Issue number3-4
DOIs
Publication statusPublished - márc. 1 2013

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

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