Four hours after oral administration of cholestyramine (1.0 g/kg) the biliary output of bile acids decreased to 21 per cent of the control value. The biliary excretion of indocyanine green (ICG; 15-60 μmol/kg i.v.), rose bengal (RB; 15-60 μmol/kg i.v.), bromsulphthalein (BSP; 15-60 μmol/kg i.v.), bromcresol green (BCG;15-60 μmol/kg i.v.) and eosine (EO; 30-120 μmol/kg i.v.) was considerably depressed by cholestyramine pretreatment. The extent and duration of the reduction in the biliary excretion of organic anions in response to bile acid depletion were found to increase with their doses. In contrast, the biliary excretion rates of bromsulphthalein-glutathione conjugate (BSP-GSH; 60-240 μmol/kg i.v.) and amaranth (AM; 60-240 μmol/kg i.v.) remained unchanged following bile acid depletion. The hepatic uptake of the cholephilic agents investigated was not affected by bile acid depletion. It is concluded that the biliary excretion rates of ICG, RB, BSP, BCG and EO are dependent on the excretion rates of endogenous bile acids. The hapatic transport rates of BSP-GSH and AM, however, seem to be relatively insensitive to the biliary output of endogenous bile salts.
|Number of pages||12|
|Journal||Archives internationales de pharmacodynamie et de therapie|
|Publication status||Published - jan. 1 1980|
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