Effect of carbapenem consumption patterns on the molecular epidemiology and carbapenem resistance of Acinetobacter baumannii

Julianna Mózes, Fatemeh Ebrahimi, Orsolya Gorácz, Cecília Miszti, G. Kardos

Research output: Article

8 Citations (Scopus)

Abstract

This study investigated the molecular epidemiology of Acinetobacter baumannii in the University of Debrecen in relation to antibiotic consumption. Overall and ward-specific antibiotic consumption was measured by the number of defined daily doses (DDD) per 100 bed-days between 2002 and 2012. Consumption was analysed against the number of A. baumannii positive patients per 100 bed-days, number of isolates per positive sample, and proportion of carbapenem resistant A. baumannii, using time-series analysis. Altogether 160 A. baumannii isolates from different wards were collected and analysed. Carbapenemase genes blaOXA-23-like, blaOXA-24-like, blaOXA-48-like, blaOXA-51-like, blaOXA-58-like and integrons were sought by PCR. Relatedness of isolates was assessed by PFGE. Prevalence and carbapenem resistance of A. baumannii were statistically associated with carbapenem consumption. Prevalence data followed carbapenem usage with three quarterly lags (r=0.51–0.53, P

Original languageEnglish
Article number082818
Pages (from-to)1654-1662
Number of pages9
JournalJournal of Medical Microbiology
Volume63
DOIs
Publication statusPublished - dec. 1 2014

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Acinetobacter baumannii
Carbapenems
Molecular Epidemiology
Integrons
Anti-Bacterial Agents
Polymerase Chain Reaction
Genes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology
  • Medicine(all)

Cite this

Effect of carbapenem consumption patterns on the molecular epidemiology and carbapenem resistance of Acinetobacter baumannii. / Mózes, Julianna; Ebrahimi, Fatemeh; Gorácz, Orsolya; Miszti, Cecília; Kardos, G.

In: Journal of Medical Microbiology, Vol. 63, 082818, 01.12.2014, p. 1654-1662.

Research output: Article

Mózes, Julianna ; Ebrahimi, Fatemeh ; Gorácz, Orsolya ; Miszti, Cecília ; Kardos, G. / Effect of carbapenem consumption patterns on the molecular epidemiology and carbapenem resistance of Acinetobacter baumannii. In: Journal of Medical Microbiology. 2014 ; Vol. 63. pp. 1654-1662.
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