EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes

B. Clemens, S. Puskás, M. Besenyei, M. Emri, G. Opposits, S. A. Kis, K. Hollódy, A. Fogarasi, I. Kondákor, K. Füle, K. Bense, I. Fekete

Research output: Article

7 Citations (Scopus)

Abstract

Objective: We tested the hypothesis that the cortical areas with abnormal local EEG synchronization are dissimilar in the three common idiopathic generalized epilepsy (IGE) phenotypes: IGE patients with absence seizures (ABS), juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures exclusively (EGTCS). Patients and methods: Groups of unmedicated ABS, JME and EGTCS patients were investigated. Waking EEG background activity (without any epileptiform potentials) was analyzed by a source localization method, LORETA (Low Resolution Electromagnetic Tomography). Each patient group was compared to a separate, age-matched group of healthy control persons. Voxel-based, normalized broad-band (delta, theta, alpha, and beta) and very narrow band (VNB, 1Hz bandwidth, from 1 to 25Hz) LORETA activity (=current source density, A/m2) were computed for each person. Group comparison included subtraction (average patient data minus average control data) and group statistics (multiple t-tests, where Bonferroni-corrected p

Original languageEnglish
Pages (from-to)281-292
Number of pages12
JournalEpilepsy Research
Volume99
Issue number3
DOIs
Publication statusPublished - máj. 2012

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Endophenotypes
Electromagnetic Phenomena
Electroencephalography
Tomography
Juvenile Myoclonic Epilepsy
Absence Epilepsy
Generalized Epilepsy
Seizures
Research Design
Age Groups
Idiopathic Generalized Epilepsy
Phenotype
Control Groups

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes. / Clemens, B.; Puskás, S.; Besenyei, M.; Emri, M.; Opposits, G.; Kis, S. A.; Hollódy, K.; Fogarasi, A.; Kondákor, I.; Füle, K.; Bense, K.; Fekete, I.

In: Epilepsy Research, Vol. 99, No. 3, 05.2012, p. 281-292.

Research output: Article

Clemens, B. ; Puskás, S. ; Besenyei, M. ; Emri, M. ; Opposits, G. ; Kis, S. A. ; Hollódy, K. ; Fogarasi, A. ; Kondákor, I. ; Füle, K. ; Bense, K. ; Fekete, I. / EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes. In: Epilepsy Research. 2012 ; Vol. 99, No. 3. pp. 281-292.
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