Early pregnancy loss, premature and low birth weight delivery, and increased maternal lymphocyte cytotoxicity

P. J. Varga, Z. Szereday, A. Artner, J. Szekeres-Barthó

Research output: Article

7 Citations (Scopus)

Abstract

Lymphocytes of 628 pregnant women were tested for natural cytotoxic activity to human embryonic fibroblast cells. The data were analyzed with regard to previous obstetric history, symptoms occurring during the present gestation, and the outcome of pregnancy. The normal rate of cytotoxicity during pregnancy was established by determining cytotoxic activity of the lymphocytes from 56 healthy pregnant women. The values higher than the mean + 2 SD of the 'normal' (≥ 40%) were considered as high. Increased cytotoxicity was associated with the occurrence of previous spontaneous and missed abortions, as well as with bleeding and uterine contractions during the present pregnancy observed at the time of the test. In 15 out of 35 cases resulting in spontaneous abortion and 15 out of the 34 pregnancies resulting in missed abortion, cytotoxic activity of the lymphocytes during pregnancy was higher than normal. Similarly, in 38 and 32.7% of the pregnancies resulting in preterm (n = 121) or low birthweight deliveries (n = 101) respectively, we found increased lymphocyte cytotoxicity, in contrast to that being found in 5.4% of uncomplicated normal pregnancies. These data suggest that at least some pregnancy failures might be immunologically mediated.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume19
Issue number4
Publication statusPublished - 1989

Fingerprint

Premature Birth
Low Birth Weight Infant
Mothers
Lymphocytes
Pregnancy
Missed Abortion
Spontaneous Abortion
Pregnant Women
Uterine Contraction
Induced Abortion
Pregnancy Outcome
Human Activities
Obstetrics
Fibroblasts
History
Hemorrhage

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

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title = "Early pregnancy loss, premature and low birth weight delivery, and increased maternal lymphocyte cytotoxicity",
abstract = "Lymphocytes of 628 pregnant women were tested for natural cytotoxic activity to human embryonic fibroblast cells. The data were analyzed with regard to previous obstetric history, symptoms occurring during the present gestation, and the outcome of pregnancy. The normal rate of cytotoxicity during pregnancy was established by determining cytotoxic activity of the lymphocytes from 56 healthy pregnant women. The values higher than the mean + 2 SD of the 'normal' (≥ 40{\%}) were considered as high. Increased cytotoxicity was associated with the occurrence of previous spontaneous and missed abortions, as well as with bleeding and uterine contractions during the present pregnancy observed at the time of the test. In 15 out of 35 cases resulting in spontaneous abortion and 15 out of the 34 pregnancies resulting in missed abortion, cytotoxic activity of the lymphocytes during pregnancy was higher than normal. Similarly, in 38 and 32.7{\%} of the pregnancies resulting in preterm (n = 121) or low birthweight deliveries (n = 101) respectively, we found increased lymphocyte cytotoxicity, in contrast to that being found in 5.4{\%} of uncomplicated normal pregnancies. These data suggest that at least some pregnancy failures might be immunologically mediated.",
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T1 - Early pregnancy loss, premature and low birth weight delivery, and increased maternal lymphocyte cytotoxicity

AU - Varga, P. J.

AU - Szereday, Z.

AU - Artner, A.

AU - Szekeres-Barthó, J.

PY - 1989

Y1 - 1989

N2 - Lymphocytes of 628 pregnant women were tested for natural cytotoxic activity to human embryonic fibroblast cells. The data were analyzed with regard to previous obstetric history, symptoms occurring during the present gestation, and the outcome of pregnancy. The normal rate of cytotoxicity during pregnancy was established by determining cytotoxic activity of the lymphocytes from 56 healthy pregnant women. The values higher than the mean + 2 SD of the 'normal' (≥ 40%) were considered as high. Increased cytotoxicity was associated with the occurrence of previous spontaneous and missed abortions, as well as with bleeding and uterine contractions during the present pregnancy observed at the time of the test. In 15 out of 35 cases resulting in spontaneous abortion and 15 out of the 34 pregnancies resulting in missed abortion, cytotoxic activity of the lymphocytes during pregnancy was higher than normal. Similarly, in 38 and 32.7% of the pregnancies resulting in preterm (n = 121) or low birthweight deliveries (n = 101) respectively, we found increased lymphocyte cytotoxicity, in contrast to that being found in 5.4% of uncomplicated normal pregnancies. These data suggest that at least some pregnancy failures might be immunologically mediated.

AB - Lymphocytes of 628 pregnant women were tested for natural cytotoxic activity to human embryonic fibroblast cells. The data were analyzed with regard to previous obstetric history, symptoms occurring during the present gestation, and the outcome of pregnancy. The normal rate of cytotoxicity during pregnancy was established by determining cytotoxic activity of the lymphocytes from 56 healthy pregnant women. The values higher than the mean + 2 SD of the 'normal' (≥ 40%) were considered as high. Increased cytotoxicity was associated with the occurrence of previous spontaneous and missed abortions, as well as with bleeding and uterine contractions during the present pregnancy observed at the time of the test. In 15 out of 35 cases resulting in spontaneous abortion and 15 out of the 34 pregnancies resulting in missed abortion, cytotoxic activity of the lymphocytes during pregnancy was higher than normal. Similarly, in 38 and 32.7% of the pregnancies resulting in preterm (n = 121) or low birthweight deliveries (n = 101) respectively, we found increased lymphocyte cytotoxicity, in contrast to that being found in 5.4% of uncomplicated normal pregnancies. These data suggest that at least some pregnancy failures might be immunologically mediated.

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