Dynamics of sleep oscillations is coupled to brain temperature on multiple scales

Márton Csernai, Sándor Borbély, Kinga Kocsis, Dávid Burka, Zoltán Fekete, Veronika Balogh, Szabolcs Káli, Z. Emri, P. Barthó

Research output: Article

Abstract

Key points: Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs of infra-slow oscillation. Abstract: Every form of neural activity depends on temperature, yet its relationship to brain rhythms is poorly understood. In this work we examined how sleep spindles are influenced by changing brain temperatures and how brain temperature is influenced by sleep oscillations. We employed a novel thermoelectrode designed for measuring temperature while recording neural activity. We found that spindle frequency is positively correlated and duration negatively correlated with brain temperature. Local heating of the thalamus replicated the temperature dependence of spindle parameters in the heated area only, suggesting biophysical rather than global modulatory mechanisms, a finding also supported by a thalamic network model. Finally, we show that switches between oscillatory states also influence brain temperature on a shorter and smaller scale. Epochs of paradoxical sleep as well as the infra-slow oscillation were associated with brain temperature fluctuations below 0.2°C. Our results highlight that brain temperature is massively intertwined with sleep oscillations on various time scales.

Original languageEnglish
JournalJournal of Physiology
DOIs
Publication statusPublished - jan. 1 2019

Fingerprint

Sleep
Temperature
Brain
REM Sleep
Thalamus
Heating
Anesthesia

ASJC Scopus subject areas

  • Physiology

Cite this

Dynamics of sleep oscillations is coupled to brain temperature on multiple scales. / Csernai, Márton; Borbély, Sándor; Kocsis, Kinga; Burka, Dávid; Fekete, Zoltán; Balogh, Veronika; Káli, Szabolcs; Emri, Z.; Barthó, P.

In: Journal of Physiology, 01.01.2019.

Research output: Article

Csernai, Márton ; Borbély, Sándor ; Kocsis, Kinga ; Burka, Dávid ; Fekete, Zoltán ; Balogh, Veronika ; Káli, Szabolcs ; Emri, Z. ; Barthó, P. / Dynamics of sleep oscillations is coupled to brain temperature on multiple scales. In: Journal of Physiology. 2019.
@article{f57c030851a44d45b38a48264475020e,
title = "Dynamics of sleep oscillations is coupled to brain temperature on multiple scales",
abstract = "Key points: Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs of infra-slow oscillation. Abstract: Every form of neural activity depends on temperature, yet its relationship to brain rhythms is poorly understood. In this work we examined how sleep spindles are influenced by changing brain temperatures and how brain temperature is influenced by sleep oscillations. We employed a novel thermoelectrode designed for measuring temperature while recording neural activity. We found that spindle frequency is positively correlated and duration negatively correlated with brain temperature. Local heating of the thalamus replicated the temperature dependence of spindle parameters in the heated area only, suggesting biophysical rather than global modulatory mechanisms, a finding also supported by a thalamic network model. Finally, we show that switches between oscillatory states also influence brain temperature on a shorter and smaller scale. Epochs of paradoxical sleep as well as the infra-slow oscillation were associated with brain temperature fluctuations below 0.2°C. Our results highlight that brain temperature is massively intertwined with sleep oscillations on various time scales.",
keywords = "brain temperature, infra-slow oscillation, sleep spindles, thalamus",
author = "M{\'a}rton Csernai and S{\'a}ndor Borb{\'e}ly and Kinga Kocsis and D{\'a}vid Burka and Zolt{\'a}n Fekete and Veronika Balogh and Szabolcs K{\'a}li and Z. Emri and P. Barth{\'o}",
year = "2019",
month = "1",
day = "1",
doi = "10.1113/JP277664",
language = "English",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Dynamics of sleep oscillations is coupled to brain temperature on multiple scales

AU - Csernai, Márton

AU - Borbély, Sándor

AU - Kocsis, Kinga

AU - Burka, Dávid

AU - Fekete, Zoltán

AU - Balogh, Veronika

AU - Káli, Szabolcs

AU - Emri, Z.

AU - Barthó, P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Key points: Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs of infra-slow oscillation. Abstract: Every form of neural activity depends on temperature, yet its relationship to brain rhythms is poorly understood. In this work we examined how sleep spindles are influenced by changing brain temperatures and how brain temperature is influenced by sleep oscillations. We employed a novel thermoelectrode designed for measuring temperature while recording neural activity. We found that spindle frequency is positively correlated and duration negatively correlated with brain temperature. Local heating of the thalamus replicated the temperature dependence of spindle parameters in the heated area only, suggesting biophysical rather than global modulatory mechanisms, a finding also supported by a thalamic network model. Finally, we show that switches between oscillatory states also influence brain temperature on a shorter and smaller scale. Epochs of paradoxical sleep as well as the infra-slow oscillation were associated with brain temperature fluctuations below 0.2°C. Our results highlight that brain temperature is massively intertwined with sleep oscillations on various time scales.

AB - Key points: Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs of infra-slow oscillation. Abstract: Every form of neural activity depends on temperature, yet its relationship to brain rhythms is poorly understood. In this work we examined how sleep spindles are influenced by changing brain temperatures and how brain temperature is influenced by sleep oscillations. We employed a novel thermoelectrode designed for measuring temperature while recording neural activity. We found that spindle frequency is positively correlated and duration negatively correlated with brain temperature. Local heating of the thalamus replicated the temperature dependence of spindle parameters in the heated area only, suggesting biophysical rather than global modulatory mechanisms, a finding also supported by a thalamic network model. Finally, we show that switches between oscillatory states also influence brain temperature on a shorter and smaller scale. Epochs of paradoxical sleep as well as the infra-slow oscillation were associated with brain temperature fluctuations below 0.2°C. Our results highlight that brain temperature is massively intertwined with sleep oscillations on various time scales.

KW - brain temperature

KW - infra-slow oscillation

KW - sleep spindles

KW - thalamus

UR - http://www.scopus.com/inward/record.url?scp=85068711901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068711901&partnerID=8YFLogxK

U2 - 10.1113/JP277664

DO - 10.1113/JP277664

M3 - Article

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

ER -