Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors

Narasimman Gurusamy, Istvan Lekli, Md Kaimul Ahsan, Diptarka Ray, Subhendu Mukherjee, Eduardo Mascareno, M. A.Q. Siddiqui, Dipak K. Das

Research output: Article

2 Citations (Scopus)

Abstract

CLP-1, the mouse homologue of human Hexim1 protein, exerts inhibitory control on transcriptional elongation factor-b of RNA transcript elongation. Previously, we have demonstrated that downregulation of cardiac lineage protein-1 (CLP-1) in CLP-1+/- heterozygous mice affords cardioprotection against ischemia-reperfusion injury. Our current study results show that the improvement in cardiac function in CLP-1+/- mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling and their molecular targets including redox effector factor-1, nuclear factor erythroid 2-related factor, and NADPH oxidase 4 and the active usage of thioredoxin-1, thioredoxin-2, glutaredoxin-1 and glutaredoxin-2. Our results suggest that drugs designed to down regulate CLP-1 could confer cardioprotection through the potentiation of redox cycling.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalFEBS letters
Volume584
Issue number1
DOIs
Publication statusPublished - jan. 4 2010

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Gurusamy, N., Lekli, I., Ahsan, M. K., Ray, D., Mukherjee, S., Mascareno, E., Siddiqui, M. A. Q., & Das, D. K. (2010). Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors. FEBS letters, 584(1), 187-193. https://doi.org/10.1016/j.febslet.2009.11.054