Objectives To examine the association between vagotomy and multiple sclerosis. Methods We conducted a matched cohort study of all patients who underwent truncal or super-selective vagotomy and a comparison cohort, by linking Danish population-based medical registries (1977−1995). Hazard ratios (HRs) for multiple sclerosis, adjusting for potential confounders were computed by means of Cox regression analysis. Results Median age of multiple sclerosis onset corresponded to late onset multiple sclerosis. No association with multiple sclerosis was observed for truncal vagotomy (0–37 year adjusted HR=0.91, 95% confidence interval [CI]: 0.48–1.74) or super-selective vagotomy (0–37 year adjusted HR=1.28, 95% CI: 0.79–2.09) compared with the general population. Interpretation We found no association between vagotomy and later risk of late onset multiple sclerosis.
ASJC Scopus subject areas
- Clinical Neurology