Does the membrane's physical state control the expression of heat shock and other genes?

Laszlo Vigh, Bruno Maresca, John L. Harwood

Research output: Article

303 Citations (Scopus)


Membranes provide the structural framework that divides cells from their environment and that, in eukaryotic cells, permits compartmentation. They are not simply passive barriers that are liable to be damaged during environmental challenge or pathological states, but are involved in cellular responses and in modulating intracellular signalling. Recent data show that the expression of several genes, particularly those that respond to changes in temperature, ageing or disease, is influenced and/or controlled by the membrane's physical state. Copyright (C) 1998 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalTrends in Biochemical Sciences
Issue number10
Publication statusPublished - okt. 1 1998


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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