Divergences in diagnosing nodular breast lesions of noncarcinomatous nature

Research output: Article

5 Citations (Scopus)

Abstract

Nodular breast lesions of noncarcinomatous origin are often of fibroepithelial origin. They may cause classification problems when they are hypocellular or hypercellular; the latter setting may also raise the differential diagnosis of phyllodes tumors. Thirty equivocal nodular breast lesions were collected and one hematoxylin and eosin slide from each was assessed by six pathologists with special interest in breast pathology. The overall reproducibility of classifying these lesions into categories of fibroadenoma, phyllodes tumor or anything else was moderate (kappa value: 0.48). The lack of a uniform nomenclature was not felt disturbing for hypocellular lesions, but the discordant diagnosis of tumors resembling or representing phyllodes tumors was acknowledged to require intervention, such as more obvious implication of guidelines and quality assurance programs aiming at assessing diagnoses and prognostic parameters.

Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalPathology and Oncology Research
Volume12
Issue number4
Publication statusPublished - dec. 31 2006

Fingerprint

Phyllodes Tumor
Breast
Fibroadenoma
Hematoxylin
Eosine Yellowish-(YS)
Terminology
Differential Diagnosis
Guidelines
Pathology
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

@article{075879199150401199bc74506db9880b,
title = "Divergences in diagnosing nodular breast lesions of noncarcinomatous nature",
abstract = "Nodular breast lesions of noncarcinomatous origin are often of fibroepithelial origin. They may cause classification problems when they are hypocellular or hypercellular; the latter setting may also raise the differential diagnosis of phyllodes tumors. Thirty equivocal nodular breast lesions were collected and one hematoxylin and eosin slide from each was assessed by six pathologists with special interest in breast pathology. The overall reproducibility of classifying these lesions into categories of fibroadenoma, phyllodes tumor or anything else was moderate (kappa value: 0.48). The lack of a uniform nomenclature was not felt disturbing for hypocellular lesions, but the discordant diagnosis of tumors resembling or representing phyllodes tumors was acknowledged to require intervention, such as more obvious implication of guidelines and quality assurance programs aiming at assessing diagnoses and prognostic parameters.",
keywords = "Fibroadenoma, Fibroepithelial breast tumors, Nodular lesions, Phyllodes tumor, Phylloid tumor",
author = "G. Cserni and Zsolt Orosz and J. Kulka and Z. S{\'a}pi and E. K{\'a}lm{\'a}n and R. Bori",
year = "2006",
month = "12",
day = "31",
language = "English",
volume = "12",
pages = "216--221",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Divergences in diagnosing nodular breast lesions of noncarcinomatous nature

AU - Cserni, G.

AU - Orosz, Zsolt

AU - Kulka, J.

AU - Sápi, Z.

AU - Kálmán, E.

AU - Bori, R.

PY - 2006/12/31

Y1 - 2006/12/31

N2 - Nodular breast lesions of noncarcinomatous origin are often of fibroepithelial origin. They may cause classification problems when they are hypocellular or hypercellular; the latter setting may also raise the differential diagnosis of phyllodes tumors. Thirty equivocal nodular breast lesions were collected and one hematoxylin and eosin slide from each was assessed by six pathologists with special interest in breast pathology. The overall reproducibility of classifying these lesions into categories of fibroadenoma, phyllodes tumor or anything else was moderate (kappa value: 0.48). The lack of a uniform nomenclature was not felt disturbing for hypocellular lesions, but the discordant diagnosis of tumors resembling or representing phyllodes tumors was acknowledged to require intervention, such as more obvious implication of guidelines and quality assurance programs aiming at assessing diagnoses and prognostic parameters.

AB - Nodular breast lesions of noncarcinomatous origin are often of fibroepithelial origin. They may cause classification problems when they are hypocellular or hypercellular; the latter setting may also raise the differential diagnosis of phyllodes tumors. Thirty equivocal nodular breast lesions were collected and one hematoxylin and eosin slide from each was assessed by six pathologists with special interest in breast pathology. The overall reproducibility of classifying these lesions into categories of fibroadenoma, phyllodes tumor or anything else was moderate (kappa value: 0.48). The lack of a uniform nomenclature was not felt disturbing for hypocellular lesions, but the discordant diagnosis of tumors resembling or representing phyllodes tumors was acknowledged to require intervention, such as more obvious implication of guidelines and quality assurance programs aiming at assessing diagnoses and prognostic parameters.

KW - Fibroadenoma

KW - Fibroepithelial breast tumors

KW - Nodular lesions

KW - Phyllodes tumor

KW - Phylloid tumor

UR - http://www.scopus.com/inward/record.url?scp=33847068719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847068719&partnerID=8YFLogxK

M3 - Article

C2 - 17189984

AN - SCOPUS:33847068719

VL - 12

SP - 216

EP - 221

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

IS - 4

ER -