Distinct penetrance of obesity-associated susceptibility alleles in the hungarian general and roma populations

Károly Nagy, Szilvia Fiatal, J. Sándor, R. Ádány

Research output: Article

2 Citations (Scopus)

Abstract

Aims: The aim of our study was to explore differences in genetic predisposition to obesity between the Hungarian general and Roma populations. Methods: A total of 1,152 samples from the Hungarian Roma population and 1,743 samples from the Hungarian general population were genotyped for 20 single nucleotide polymorphisms (SNPs) associated with the risk of obesity. Two types of multilocus genetic risk scores were constructed to estimate the combined effect of selected SNPs. Results: Risk allele frequencies differed significantly between the two populations for 11 SNPs, with no enrichment in any of the two study groups. Variants (rs1558902, rs1121980, rs9939609, and rs9941349) in the fat mass and obesity-associated (FTO) gene exhibited strong but ethnicity-independent association with obesity. Genetic risk scores showed stronger associations with obesity in the Roma population compared with the Hungarian general population; however, without significant gene-population interaction. Conclusion: Differences in obesity prevalence between the Hungarian general and Hungarian Roma populations could not be explained by their distinct genetic susceptibility, rather by ethnicity-related environmental and behavioral factors. Nonetheless, particular gene-environment interactions might contribute to the distinct penetrance of the obesity-associated genetic factors in populations of different ethnic backgrounds.

Original languageEnglish
Pages (from-to)444-457
Number of pages14
JournalObesity Facts
Volume10
Issue number5
DOIs
Publication statusPublished - nov. 1 2017

Fingerprint

Roma
Penetrance
gipsy
Obesity
Alleles
Population
Single Nucleotide Polymorphism
Genetic Predisposition to Disease
ethnicity
Gene-Environment Interaction
heredity
study group
interaction
Gene Frequency
Genes
Fats

ASJC Scopus subject areas

  • Health(social science)
  • Physiology (medical)

Cite this

Distinct penetrance of obesity-associated susceptibility alleles in the hungarian general and roma populations. / Nagy, Károly; Fiatal, Szilvia; Sándor, J.; Ádány, R.

In: Obesity Facts, Vol. 10, No. 5, 01.11.2017, p. 444-457.

Research output: Article

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