Disorders of phagocytic cells

Nima Rezaei, Asghar Aghamohammadi, Michael H. Albert, Bernd H. Belohradsky, Teresa Espanol, Melinda Erdős, Christoph Klein, László Maródi, Payam Mohammadinejad, Thomas Nicolai, Gundula Notheis, Mona Hedayat, Shabnam Pourhamdi, Joachim Roesler, Sergio D. Rosenzweig, Uwe Wintergerst

Research output: Chapter

Abstract

Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiology of the disorder has also affected patient management by allowing specific, targeted immunomodulatory interventions. The cases in this chapter are not common but have had a significant impact on our understanding of the role of phagocytic cells in host defense. Conversely, understanding the role of the neutrophils and macrophages in infection has benefited not just the patients described in this chapter but also other patients with similar disease process.

Original languageEnglish
Title of host publicationClinical Cases in Primary Immunodeficiency Diseases
Subtitle of host publicationA Problem-Solving Approach
PublisherSpringer Berlin Heidelberg
Pages193-231
Number of pages39
ISBN (Electronic)9783642317859
ISBN (Print)9783642317842
DOIs
Publication statusPublished - jan. 1 2012

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ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Rezaei, N., Aghamohammadi, A., Albert, M. H., Belohradsky, B. H., Espanol, T., Erdős, M., Klein, C., Maródi, L., Mohammadinejad, P., Nicolai, T., Notheis, G., Hedayat, M., Pourhamdi, S., Roesler, J., Rosenzweig, S. D., & Wintergerst, U. (2012). Disorders of phagocytic cells. In Clinical Cases in Primary Immunodeficiency Diseases: A Problem-Solving Approach (pp. 193-231). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-31785-9_4