Abstract
Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiology of the disorder has also affected patient management by allowing specific, targeted immunomodulatory interventions. The cases in this chapter are not common but have had a significant impact on our understanding of the role of phagocytic cells in host defense. Conversely, understanding the role of the neutrophils and macrophages in infection has benefited not just the patients described in this chapter but also other patients with similar disease process.
| Original language | English |
|---|---|
| Title of host publication | Clinical Cases in Primary Immunodeficiency Diseases: A Problem-Solving Approach |
| Publisher | Springer Berlin Heidelberg |
| Pages | 193-231 |
| Number of pages | 39 |
| ISBN (Print) | 9783642317859, 9783642317842 |
| DOIs | |
| Publication status | Published - jan. 1 2012 |
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ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
Cite this
Disorders of phagocytic cells. / Rezaei, Nima; Aghamohammadi, Asghar; Albert, Michael H.; Belohradsky, Bernd H.; Espanol, Teresa; Erdős, M.; Klein, Christoph; Máródi, L.; Mohammadinejad, Payam; Nicolai, Thomas; Notheis, Gundula; Hedayat, Mona; Pourhamdi, Shabnam; Roesler, Joachim; Rosenzweig, Sergio D.; Wintergerst, Uwe.
Clinical Cases in Primary Immunodeficiency Diseases: A Problem-Solving Approach. Springer Berlin Heidelberg, 2012. p. 193-231.Research output: Chapter
}
TY - CHAP
T1 - Disorders of phagocytic cells
AU - Rezaei, Nima
AU - Aghamohammadi, Asghar
AU - Albert, Michael H.
AU - Belohradsky, Bernd H.
AU - Espanol, Teresa
AU - Erdős, M.
AU - Klein, Christoph
AU - Máródi, L.
AU - Mohammadinejad, Payam
AU - Nicolai, Thomas
AU - Notheis, Gundula
AU - Hedayat, Mona
AU - Pourhamdi, Shabnam
AU - Roesler, Joachim
AU - Rosenzweig, Sergio D.
AU - Wintergerst, Uwe
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiology of the disorder has also affected patient management by allowing specific, targeted immunomodulatory interventions. The cases in this chapter are not common but have had a significant impact on our understanding of the role of phagocytic cells in host defense. Conversely, understanding the role of the neutrophils and macrophages in infection has benefited not just the patients described in this chapter but also other patients with similar disease process.
AB - Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiology of the disorder has also affected patient management by allowing specific, targeted immunomodulatory interventions. The cases in this chapter are not common but have had a significant impact on our understanding of the role of phagocytic cells in host defense. Conversely, understanding the role of the neutrophils and macrophages in infection has benefited not just the patients described in this chapter but also other patients with similar disease process.
UR - http://www.scopus.com/inward/record.url?scp=84955691839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955691839&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-31785-9_4
DO - 10.1007/978-3-642-31785-9_4
M3 - Chapter
AN - SCOPUS:84955691839
SN - 9783642317859
SN - 9783642317842
SP - 193
EP - 231
BT - Clinical Cases in Primary Immunodeficiency Diseases: A Problem-Solving Approach
PB - Springer Berlin Heidelberg
ER -