Differences in the mechanisms of the thermoregulatory impairment induced by capsaicin in newborn and adult rats.

F. Obál, G. Jancsó, M. Hajós, F. Obál

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Abstract

The function of heat defence was compared in rats pretreated as adults (A-rats) and neonates (N-rats) with capsaicin. The thermoregulatory impairment as tested by whole body heating was similar in A-rats and N-rats. The thermosensitivity and chemosensitivity of the preoptic region (RPO) seemed to be normal in N-rats. A deficiency of RPO mechanisms could be demonstrated in A-rats. It is suggested that the preoptic effects of capsaicin have but a minor significance for the thermoregulatory impairment. It seems that the main cause of decreased heat tolerance is a reduction of peripheral warm sensation due to degeneration of unmyelinated C-fibre primary neurons in both A-rats and N-rats. The results do not support the primary importance of preoptic warm sensation in physiological thermoregulation.

Original languageEnglish
Pages (from-to)437-445
Number of pages9
JournalActa physiologica Hungarica
Volume69
Issue number3-4
Publication statusPublished - 1987

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ASJC Scopus subject areas

  • Physiology (medical)

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