Differences in killing activity of caspofungin and paradoxical growth between Candida albicans and C. krusei clinical isolates in different media

I. Varga, G. Sóczó, G. Kardos, Á Kemény-Beke, B. Kelentey, I. Márton, László Majoros

Research output: Article

2 Citations (Scopus)

Abstract

Minimum fungicidal concentration (MFC) of caspofungin was determined against 16 Candida albicans and 16 C. krusei in RPMI-1640 and antibiotic medium 3 (AM3). Time-kill tests were performed on six C. albicans and four C. krusei strains at 0.06-16 mg/L caspofungin. MFC ranges after 48 h were 0.5-1 and 1-2 mg/L for C. albicans and C. krusei, respectively; one C. albicans and the C. krusei reference strain showed paradoxical growth (PG) in RPMI-1640, respectively. In killing experiments, after 48 h caspofugin was fungicidal against two and four C. albicans in RPMI-1640 (at 16 mg/L) and in AM3 (at 0.5 mg/L), respectively; PG was noted in three and two cases, respectively. Caspofungin at 2 and 0.5 mg/ L was fungicidal against all tested C. krusei strains even after 24 h in RPMI-1640 and AM3, respectively. Killing activity of caspofungin against C. albicans and C. krusei could be exactly measured only by killing curves.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalJournal of Chemotherapy
Volume21
Issue number1
Publication statusPublished - márc. 31 2009

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ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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