Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

Kyojiro Kawakami, Akihiro Nakamura, Sataro Goto

Research output: Article

13 Citations (Scopus)


We studied dietary restriction (DR) related changes of site-specific acetylation of histone H3 in rat livers to explore a possible link to histone modifications and sirtuin levels with anti-aging effects of DR. The acetylation at lysine residue 9, 27 and 56 in H3 was 20-30% higher in DR animals compared with ad libitum fed counterparts. SIRT6, one of histone deacetylases, was significantly decreased by DR and thereby may be involved in an increase in the histone acetylation. Our findings suggest that upregulation of chromatin activities through increased histone acetylation is a mechanism of anti-aging effects of DR.

Original languageEnglish
Pages (from-to)836-840
Number of pages5
JournalBiochemical and biophysical research communications
Issue number4
Publication statusPublished - febr. 24 2012


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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