A tumormarkerek diagnosztikus értéke a fül-orr-gégészeti onkológiában.

L. Tamás, I. Sziklai, O. Ribári

Research output: Article

1 Citation (Scopus)

Abstract

Control serum samples of young, healthy volunteers (N = 5) were compared with serum samples and laryngeal cancer extracts of patients (N = 12) with stage 3 and 4 cancers. Eight patients were primarily treated by total laryngectomy, 4 patient by palliative irradiation therapy (60 Gy). Ethanol (80%, pH 2) extracts of sera and cancer specimen were gel chromatographed, and the nominally 0.3-5 KDa molecular mass substances were further examined by analytical capillary isotachophoresis (ITP) (LKB. Sweden). Serum samples were also examined after surgery of irradiation therapy. Serum and tumor extracts of each laryngeal cancer patient contained a substance in the molecular mass range of 0.3-5 kDa. This was not detected in the serum of normal control subjects. The marker-candidate substance disappeared from the serum of four out of 8 laryngectomized patients who live tumor-free for years. Recurrence or lymph node metastasis developed in three of the remaining four patients who did not become free of the marker substance after laryngectomy. The concentration of the marker has been increased in the serum after palliative irradiation in all four patients. This marker substance is probably a product of tumor necrosis. The marker may adequately monitor the recurrence of tumor postoperatively of after irradiation therapy.

Original languageHungarian
Pages (from-to)1261-1264
Number of pages4
JournalOrvosi Hetilap
Volume138
Issue number20
Publication statusPublished - máj. 18 1997

Fingerprint

Tumor Biomarkers
Serum
Neoplasms
Laryngectomy
Laryngeal Neoplasms
Isotachophoresis
Recurrence
Palliative Care
Sweden
Healthy Volunteers
Ethanol
Necrosis
Lymph Nodes
Gels
Neoplasm Metastasis
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A tumormarkerek diagnosztikus értéke a fül-orr-gégészeti onkológiában. / Tamás, L.; Sziklai, I.; Ribári, O.

In: Orvosi Hetilap, Vol. 138, No. 20, 18.05.1997, p. 1261-1264.

Research output: Article

Tamás, L. ; Sziklai, I. ; Ribári, O. / A tumormarkerek diagnosztikus értéke a fül-orr-gégészeti onkológiában. In: Orvosi Hetilap. 1997 ; Vol. 138, No. 20. pp. 1261-1264.
@article{c0becc12b097454490894a2861f7179b,
title = "A tumormarkerek diagnosztikus {\'e}rt{\'e}ke a f{\"u}l-orr-g{\'e}g{\'e}szeti onkol{\'o}gi{\'a}ban.",
abstract = "Control serum samples of young, healthy volunteers (N = 5) were compared with serum samples and laryngeal cancer extracts of patients (N = 12) with stage 3 and 4 cancers. Eight patients were primarily treated by total laryngectomy, 4 patient by palliative irradiation therapy (60 Gy). Ethanol (80{\%}, pH 2) extracts of sera and cancer specimen were gel chromatographed, and the nominally 0.3-5 KDa molecular mass substances were further examined by analytical capillary isotachophoresis (ITP) (LKB. Sweden). Serum samples were also examined after surgery of irradiation therapy. Serum and tumor extracts of each laryngeal cancer patient contained a substance in the molecular mass range of 0.3-5 kDa. This was not detected in the serum of normal control subjects. The marker-candidate substance disappeared from the serum of four out of 8 laryngectomized patients who live tumor-free for years. Recurrence or lymph node metastasis developed in three of the remaining four patients who did not become free of the marker substance after laryngectomy. The concentration of the marker has been increased in the serum after palliative irradiation in all four patients. This marker substance is probably a product of tumor necrosis. The marker may adequately monitor the recurrence of tumor postoperatively of after irradiation therapy.",
author = "L. Tam{\'a}s and I. Sziklai and O. Rib{\'a}ri",
year = "1997",
month = "5",
day = "18",
language = "Hungarian",
volume = "138",
pages = "1261--1264",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "20",

}

TY - JOUR

T1 - A tumormarkerek diagnosztikus értéke a fül-orr-gégészeti onkológiában.

AU - Tamás, L.

AU - Sziklai, I.

AU - Ribári, O.

PY - 1997/5/18

Y1 - 1997/5/18

N2 - Control serum samples of young, healthy volunteers (N = 5) were compared with serum samples and laryngeal cancer extracts of patients (N = 12) with stage 3 and 4 cancers. Eight patients were primarily treated by total laryngectomy, 4 patient by palliative irradiation therapy (60 Gy). Ethanol (80%, pH 2) extracts of sera and cancer specimen were gel chromatographed, and the nominally 0.3-5 KDa molecular mass substances were further examined by analytical capillary isotachophoresis (ITP) (LKB. Sweden). Serum samples were also examined after surgery of irradiation therapy. Serum and tumor extracts of each laryngeal cancer patient contained a substance in the molecular mass range of 0.3-5 kDa. This was not detected in the serum of normal control subjects. The marker-candidate substance disappeared from the serum of four out of 8 laryngectomized patients who live tumor-free for years. Recurrence or lymph node metastasis developed in three of the remaining four patients who did not become free of the marker substance after laryngectomy. The concentration of the marker has been increased in the serum after palliative irradiation in all four patients. This marker substance is probably a product of tumor necrosis. The marker may adequately monitor the recurrence of tumor postoperatively of after irradiation therapy.

AB - Control serum samples of young, healthy volunteers (N = 5) were compared with serum samples and laryngeal cancer extracts of patients (N = 12) with stage 3 and 4 cancers. Eight patients were primarily treated by total laryngectomy, 4 patient by palliative irradiation therapy (60 Gy). Ethanol (80%, pH 2) extracts of sera and cancer specimen were gel chromatographed, and the nominally 0.3-5 KDa molecular mass substances were further examined by analytical capillary isotachophoresis (ITP) (LKB. Sweden). Serum samples were also examined after surgery of irradiation therapy. Serum and tumor extracts of each laryngeal cancer patient contained a substance in the molecular mass range of 0.3-5 kDa. This was not detected in the serum of normal control subjects. The marker-candidate substance disappeared from the serum of four out of 8 laryngectomized patients who live tumor-free for years. Recurrence or lymph node metastasis developed in three of the remaining four patients who did not become free of the marker substance after laryngectomy. The concentration of the marker has been increased in the serum after palliative irradiation in all four patients. This marker substance is probably a product of tumor necrosis. The marker may adequately monitor the recurrence of tumor postoperatively of after irradiation therapy.

UR - http://www.scopus.com/inward/record.url?scp=0031577002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031577002&partnerID=8YFLogxK

M3 - Article

C2 - 9244860

AN - SCOPUS:0031577002

VL - 138

SP - 1261

EP - 1264

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 20

ER -