A hepatitis B- és D-vírus-fertőzés diagnosztikája, antivirális kezelése. Magyar konszenzusajánlás. Érvényes: 2016. október 15-től

Gábor Horváth, Zsuzsanna Gerlei, Judit Gervain, G. Lengyel, Mihály Makara, A. Pár, László Rókusz, F. Szalay, István Tornai, Klára Werling, B. Hunyady

Research output: Article

1 Citation (Scopus)

Abstract

Diagnosis and treatment of HBV/HDV infection means for the patient to be able to maintain working capacity, to increase quality of life, to prevent cancer, and to prolong life expectancy, while society benefits from eliminating the chances of further transmission of the viruses, and decreasing the overall costs of serious complications. The guideline delineates the treatment algorithms for 2017 set by a consensus meeting of physicians involved in the treatment of these diseases. The prevalence of HBV infection in the Hungarian general population is 0.5-0.7%. The indications of treatment is based upon viral examinations (including viral nucleic acid determination), determinations of disease activity and stage (including biochemical, pathologic, and/or non-invasive methods), and excluding contraindications. To avoid unnecessary side effects and for cost-effective approach the guideline stresses the importance of quick and detailed virologic evaluations, the applicability of elastography as an acceptable alternative of liver biopsy in this regard, as well as the relevance of appropriate consistent follow up schedule for viral response during therapy. The first choice of therapy in chronic hepatitis B infection can be pegylated interferon for 48 weeks or continuous entecavir or tenofovir therapy. The latter two must be continued for at least 12 months after hepatitis B surface antigen seroconversion. Adefovir dipivoxil is recommended mainly in combination therapy. Lamivudine is no longer a first choice; patients currently taking lamivudine must switch if response is inadequate. Appropriate treatment of patients taking immunosuppressive medications is highly recommended. Pegylated interferon based therapy is recommended for the treatment of concomitant hepatitis D infection. Orv. Hetil., 2017, 158(Suppl. 1) 23-35.

Original languageHungarian
Pages (from-to)23-35
Number of pages13
JournalOrvosi hetilap
Volume158
DOIs
Publication statusPublished - febr. 1 2017

Fingerprint

Chronic Hepatitis D
Hungary
Chronic Hepatitis B
Guidelines
Therapeutics
Lamivudine
Tenofovir
Infection
Interferons
Hepatitis D
Elasticity Imaging Techniques
Costs and Cost Analysis
Immunosuppressive Agents
Hepatitis B Surface Antigens
Life Expectancy
Nucleic Acids

Keywords

  • adefovir
  • cirrhosis
  • entecavir
  • hepatitis B virus
  • hepatitis B-vírus
  • hepatitis D virus
  • hepatitis D-vírus
  • interferon
  • lamivudin
  • lamivudine
  • liver cancer
  • májrák
  • májzsugor
  • pegilált interferon
  • pegylated interferon
  • tenofovir
  • viral hepatitis
  • vírushepatitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A hepatitis B- és D-vírus-fertőzés diagnosztikája, antivirális kezelése. Magyar konszenzusajánlás. Érvényes : 2016. október 15-től. / Horváth, Gábor; Gerlei, Zsuzsanna; Gervain, Judit; Lengyel, G.; Makara, Mihály; Pár, A.; Rókusz, László; Szalay, F.; Tornai, István; Werling, Klára; Hunyady, B.

In: Orvosi hetilap, Vol. 158, 01.02.2017, p. 23-35.

Research output: Article

Horváth, Gábor ; Gerlei, Zsuzsanna ; Gervain, Judit ; Lengyel, G. ; Makara, Mihály ; Pár, A. ; Rókusz, László ; Szalay, F. ; Tornai, István ; Werling, Klára ; Hunyady, B. / A hepatitis B- és D-vírus-fertőzés diagnosztikája, antivirális kezelése. Magyar konszenzusajánlás. Érvényes : 2016. október 15-től. In: Orvosi hetilap. 2017 ; Vol. 158. pp. 23-35.
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