A hepatitis B- és D-vírus-ferto{combining double acute accent}zés diagnosztikája, antivirális kezelése: Magyar konszenzusajánlás

Gábor Horváth, Zsuzsanna Gerlei, Judit Gervain, G. Lengyel, Mihály Makara, A. Pár, László Rókusz, F. Szalay, L. Telegdy, István Tornai, Klára Werling, B. Hunyady

Research output: Article

3 Citations (Scopus)

Abstract

Diagnosis and treatment of hepatitis B and D virus infections mean that the patient is able to maintain working capacity, increase quality of life, prevent cancer, and prolong life expectancy, while the society benefits from eliminating the chances of further transmission of the viruses, and decreasing the overall costs of serious complications. The guideline delineates the treatment algorithms for 2015, which is agreed on a consensus meeting of specialists involved in the treatment of the above diseases. The prevalence of hepatitis B virus infection in the Hungarian general population is 0.5-0.7%. The indications of treatment is based upon viral examinations (including viral nucleic acid determination), determinations of disease activity and stage (including biochemical, pathologic, and/or non-invasive methods), and excluding contraindications. To avoid unnecessary side effects and for cost-effective approach the guideline emphasizes the importance of quick and detailed virologic evaluations, the applicability of transient elastography as an acceptable alternative of liver biopsy in this regard, as well as the relevance of appropriate consistent follow up schedule for viral response during therapy. The first choice of therapy in chronic hepatitis B infection can be pegylated interferon for 48 weeks or continuous entecavir or tenofovir therapy. The latter two must be continued for at least 12 months after hepatitis B surface antigen seroconversion. Adefovir dipivoxil is recommended mainly in combination therapy. Lamivudine is no longer a first choice; patients currently taking lamivudine must switch if response is inadequate. Appropriate treatment of patients taking immunosuppressive medications is highly recommended. Pegylated interferon based therapy is recommended for the treatment of concomitant hepatitis D infection.

Original languageHungarian
Pages (from-to)25-35
Number of pages11
JournalOrvosi Hetilap
Volume156
DOIs
Publication statusPublished - márc. 1 2015

Fingerprint

Chronic Hepatitis D
Chronic Hepatitis B
Guidelines
Therapeutics
Lamivudine
Tenofovir
Virus Diseases
Hepatitis B virus
Interferons
Hepatitis D
Hepatitis Delta Virus
Elasticity Imaging Techniques
Costs and Cost Analysis
Immunosuppressive Agents
Hepatitis B Surface Antigens
Life Expectancy
Infection
Nucleic Acids

Keywords

  • Adefovir
  • Cirrhosis
  • Entecavir
  • Hepatitis B virus
  • Hepatitis D virus
  • Interferon
  • Lamivudine
  • Liver cancer
  • Pegylated interferon
  • Tenofovir
  • Viral hepatitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A hepatitis B- és D-vírus-ferto{combining double acute accent}zés diagnosztikája, antivirális kezelése : Magyar konszenzusajánlás. / Horváth, Gábor; Gerlei, Zsuzsanna; Gervain, Judit; Lengyel, G.; Makara, Mihály; Pár, A.; Rókusz, László; Szalay, F.; Telegdy, L.; Tornai, István; Werling, Klára; Hunyady, B.

In: Orvosi Hetilap, Vol. 156, 01.03.2015, p. 25-35.

Research output: Article

Horváth, Gábor ; Gerlei, Zsuzsanna ; Gervain, Judit ; Lengyel, G. ; Makara, Mihály ; Pár, A. ; Rókusz, László ; Szalay, F. ; Telegdy, L. ; Tornai, István ; Werling, Klára ; Hunyady, B. / A hepatitis B- és D-vírus-ferto{combining double acute accent}zés diagnosztikája, antivirális kezelése : Magyar konszenzusajánlás. In: Orvosi Hetilap. 2015 ; Vol. 156. pp. 25-35.
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abstract = "Diagnosis and treatment of hepatitis B and D virus infections mean that the patient is able to maintain working capacity, increase quality of life, prevent cancer, and prolong life expectancy, while the society benefits from eliminating the chances of further transmission of the viruses, and decreasing the overall costs of serious complications. The guideline delineates the treatment algorithms for 2015, which is agreed on a consensus meeting of specialists involved in the treatment of the above diseases. The prevalence of hepatitis B virus infection in the Hungarian general population is 0.5-0.7{\%}. The indications of treatment is based upon viral examinations (including viral nucleic acid determination), determinations of disease activity and stage (including biochemical, pathologic, and/or non-invasive methods), and excluding contraindications. To avoid unnecessary side effects and for cost-effective approach the guideline emphasizes the importance of quick and detailed virologic evaluations, the applicability of transient elastography as an acceptable alternative of liver biopsy in this regard, as well as the relevance of appropriate consistent follow up schedule for viral response during therapy. The first choice of therapy in chronic hepatitis B infection can be pegylated interferon for 48 weeks or continuous entecavir or tenofovir therapy. The latter two must be continued for at least 12 months after hepatitis B surface antigen seroconversion. Adefovir dipivoxil is recommended mainly in combination therapy. Lamivudine is no longer a first choice; patients currently taking lamivudine must switch if response is inadequate. Appropriate treatment of patients taking immunosuppressive medications is highly recommended. Pegylated interferon based therapy is recommended for the treatment of concomitant hepatitis D infection.",
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AU - Gerlei, Zsuzsanna

AU - Gervain, Judit

AU - Lengyel, G.

AU - Makara, Mihály

AU - Pár, A.

AU - Rókusz, László

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AU - Telegdy, L.

AU - Tornai, István

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