Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans

Márton Csékei, Z. Novák, András Kotschy

Research output: Article

59 Citations (Scopus)

Abstract

An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product.

Original languageEnglish
Pages (from-to)8992-8996
Number of pages5
JournalTetrahedron
Volume64
Issue number37
DOIs
Publication statusPublished - szept. 8 2008

Fingerprint

Benzofurans
Acetylene
Palladium
Biological Products
Methanol
benzofuran

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans. / Csékei, Márton; Novák, Z.; Kotschy, András.

In: Tetrahedron, Vol. 64, No. 37, 08.09.2008, p. 8992-8996.

Research output: Article

Csékei, Márton ; Novák, Z. ; Kotschy, András. / Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans. In: Tetrahedron. 2008 ; Vol. 64, No. 37. pp. 8992-8996.
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