Poorly water-soluble drugs, such as nifluminic acid -important anti-inflammatory drug- offer challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristic and thus, to poor oral bioavailibility. In order to increase the degree of dissolution and solubility of nifluminic acid, products were prepared with polyvinylpyrrolidone K-25, using physical mixing and solvent evaporation methods. The drug-polymer interactions in the solid state were investigated by using hot-stage microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The results suggested that polyvinylpyrrolidone may inhibit the association of the drug molecule to form the crystal nucleus and, thereby inhibit crystal growth. In the physical mixtures, the nifluminic acid was dissolved in the melted polyvinylpyrrolidone, whereas the solid dispersions contained nifluminic acid in the amorphous state.
|Number of pages||4|
|Journal||Revista de Chimie|
|Publication status||Published - okt. 2006|
ASJC Scopus subject areas
- Materials Science (miscellaneous)
- Surfaces, Coatings and Films
- Materials Chemistry