Determination of the structural interaction of nifluminic acid-PVP solid dispersions

Rita Ambrus, Zoltán Aigner, Ottó Berkesi, Codruţa Şoica, Piroska Szabó-Révész

Research output: Article

3 Citations (Scopus)

Abstract

Poorly water-soluble drugs, such as nifluminic acid -important anti-inflammatory drug- offer challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristic and thus, to poor oral bioavailibility. In order to increase the degree of dissolution and solubility of nifluminic acid, products were prepared with polyvinylpyrrolidone K-25, using physical mixing and solvent evaporation methods. The drug-polymer interactions in the solid state were investigated by using hot-stage microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The results suggested that polyvinylpyrrolidone may inhibit the association of the drug molecule to form the crystal nucleus and, thereby inhibit crystal growth. In the physical mixtures, the nifluminic acid was dissolved in the melted polyvinylpyrrolidone, whereas the solid dispersions contained nifluminic acid in the amorphous state.

Original languageEnglish
Pages (from-to)1051-1054
Number of pages4
JournalRevista de Chimie
Volume57
Issue number10
Publication statusPublished - okt. 2006

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ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science (miscellaneous)
  • Engineering(all)
  • Surfaces, Coatings and Films
  • Materials Chemistry

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