Determination of the lipophilicity of some aniline derivatives by reversed-phase thin-layer chromatography. The effect of salts

T. Cserháti, B. Bordás, M. Szögyi

Research output: Article

10 Citations (Scopus)

Abstract

The lipophilicity of aniline and 36 ring-substituted aniline derivatives was determined by reversed-phase thin-layer chromatography using NaCl, KCl, MgCl2, CaCl2, AlCl3 and tetramethyl-ammoniumhydroxide, either adsorbed on the silica surface before impregnation or added to the eluent. In most cases the salts decreased the retention power of silica resulting in enhanced mobility of the aniline derivatives. The monovalent cations had the lowest, while AlCl3 and tetramethylammoniumhydroxide had the highest impact on selectivity. This phenomenon can be explained by the different ion charges. The correlation between the RM values and the partition coefficient between n-octanol: water were in all cases inferior to those obtained in salt-free systems this means that the presence of salts modifies differently the lipophilicity of aniline derivatives.

Original languageEnglish
Pages (from-to)312-316
Number of pages5
JournalChromatographia
Volume21
Issue number6
DOIs
Publication statusPublished - jún. 1 1986

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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