Determination of drug-cyclodextrin binding constants by capillary zone electrophoresis

János Gyimesi, É. Szökő, K. Magyar, Lajos Barcza

Research output: Article

7 Citations (Scopus)

Abstract

Binding constants of the optical isomers of Deprenyl® (selegiline) and its potential metabolites with (2,6-di-O-methyl)-β-cyclodextrin were determined using electrophoretic mobility data gained from separations performed by capillary electrophofesis, and absorbancies obtained from spectrophotometric experiments. To calculate equilibrium constants 1:1 complex formation have been assumed. The comparison of the equilibrium constants calculated from different methods shows similar values in their order of magnitude. Their difference may probably be explained by the different media of the measurements. The effect of the structure of compounds on chiral discrimination were also elucidated.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume25
Issue number1-3
Publication statusPublished - 1996

Fingerprint

capillary zone electrophoresis
Selegiline
cyclodextrins
Equilibrium constants
Cyclodextrins
Capillary Electrophoresis
electrophoresis
Electrophoresis
isomers
drugs
metabolites
Electrophoretic mobility
Metabolites
Isomers
Pharmaceutical Preparations
discrimination
methodology
Experiments

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

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abstract = "Binding constants of the optical isomers of Deprenyl{\circledR} (selegiline) and its potential metabolites with (2,6-di-O-methyl)-β-cyclodextrin were determined using electrophoretic mobility data gained from separations performed by capillary electrophofesis, and absorbancies obtained from spectrophotometric experiments. To calculate equilibrium constants 1:1 complex formation have been assumed. The comparison of the equilibrium constants calculated from different methods shows similar values in their order of magnitude. Their difference may probably be explained by the different media of the measurements. The effect of the structure of compounds on chiral discrimination were also elucidated.",
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T1 - Determination of drug-cyclodextrin binding constants by capillary zone electrophoresis

AU - Gyimesi, János

AU - Szökő, É.

AU - Magyar, K.

AU - Barcza, Lajos

PY - 1996

Y1 - 1996

N2 - Binding constants of the optical isomers of Deprenyl® (selegiline) and its potential metabolites with (2,6-di-O-methyl)-β-cyclodextrin were determined using electrophoretic mobility data gained from separations performed by capillary electrophofesis, and absorbancies obtained from spectrophotometric experiments. To calculate equilibrium constants 1:1 complex formation have been assumed. The comparison of the equilibrium constants calculated from different methods shows similar values in their order of magnitude. Their difference may probably be explained by the different media of the measurements. The effect of the structure of compounds on chiral discrimination were also elucidated.

AB - Binding constants of the optical isomers of Deprenyl® (selegiline) and its potential metabolites with (2,6-di-O-methyl)-β-cyclodextrin were determined using electrophoretic mobility data gained from separations performed by capillary electrophofesis, and absorbancies obtained from spectrophotometric experiments. To calculate equilibrium constants 1:1 complex formation have been assumed. The comparison of the equilibrium constants calculated from different methods shows similar values in their order of magnitude. Their difference may probably be explained by the different media of the measurements. The effect of the structure of compounds on chiral discrimination were also elucidated.

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