Determination of active hydrogen in organic compounds by electron‐impact mass spectrometry

Z. Dinya, Miklós Lipták, Pál Szabó, F. Sztaricskai, K. Vékey

Research output: Article

7 Citations (Scopus)

Abstract

We report here detailed studies of Bose et al.'s (J. Org. Chem. 47, 4008 (1982)) simple method for obtaining electron‐impact (EI) mass spectra from non‐volatile and/or thermolabile organic compounds by using ammonium salts. Good quality mass spectra can be obtained by mixing the analyte with different ammonium salts (mainly with NH4Cl) in a given ratio, the mixture being introduced through a conventonal direct probe. A wide variety of ammonium salts has been used to study the effect of the anion and to determine the optimum analyte:NH4X ratio and the other experimental parameters (i.e., electron energy, source temperature etc). A very simple and cheap means of determination of active hydrogen in hydroxyl, carboxyl, sulfhydryl, amino and amido etc groups by EI mass spectrometry using deuterated ammonium chloride (ND4CI) is described. The method is based on exchange of active hydrogen for deuterium occurring in situ in the ion source. This technique allows drect comparison of spectra before and after deuteration and the number of active hydrogens can be identified in most cases. The applicability of this method is demonstrated on different model compounds.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalRapid Communications in Mass Spectrometry
Volume6
Issue number11
DOIs
Publication statusPublished - 1992

Fingerprint

Ammonium Compounds
Organic compounds
Mass spectrometry
Hydrogen
Salts
Ammonium Chloride
Deuterium
Ion sources
Hydroxyl Radical
Anions
Electrons
Temperature

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

Cite this

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title = "Determination of active hydrogen in organic compounds by electron‐impact mass spectrometry",
abstract = "We report here detailed studies of Bose et al.'s (J. Org. Chem. 47, 4008 (1982)) simple method for obtaining electron‐impact (EI) mass spectra from non‐volatile and/or thermolabile organic compounds by using ammonium salts. Good quality mass spectra can be obtained by mixing the analyte with different ammonium salts (mainly with NH4Cl) in a given ratio, the mixture being introduced through a conventonal direct probe. A wide variety of ammonium salts has been used to study the effect of the anion and to determine the optimum analyte:NH4X ratio and the other experimental parameters (i.e., electron energy, source temperature etc). A very simple and cheap means of determination of active hydrogen in hydroxyl, carboxyl, sulfhydryl, amino and amido etc groups by EI mass spectrometry using deuterated ammonium chloride (ND4CI) is described. The method is based on exchange of active hydrogen for deuterium occurring in situ in the ion source. This technique allows drect comparison of spectra before and after deuteration and the number of active hydrogens can be identified in most cases. The applicability of this method is demonstrated on different model compounds.",
author = "Z. Dinya and Mikl{\'o}s Lipt{\'a}k and P{\'a}l Szab{\'o} and F. Sztaricskai and K. V{\'e}key",
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T1 - Determination of active hydrogen in organic compounds by electron‐impact mass spectrometry

AU - Dinya, Z.

AU - Lipták, Miklós

AU - Szabó, Pál

AU - Sztaricskai, F.

AU - Vékey, K.

PY - 1992

Y1 - 1992

N2 - We report here detailed studies of Bose et al.'s (J. Org. Chem. 47, 4008 (1982)) simple method for obtaining electron‐impact (EI) mass spectra from non‐volatile and/or thermolabile organic compounds by using ammonium salts. Good quality mass spectra can be obtained by mixing the analyte with different ammonium salts (mainly with NH4Cl) in a given ratio, the mixture being introduced through a conventonal direct probe. A wide variety of ammonium salts has been used to study the effect of the anion and to determine the optimum analyte:NH4X ratio and the other experimental parameters (i.e., electron energy, source temperature etc). A very simple and cheap means of determination of active hydrogen in hydroxyl, carboxyl, sulfhydryl, amino and amido etc groups by EI mass spectrometry using deuterated ammonium chloride (ND4CI) is described. The method is based on exchange of active hydrogen for deuterium occurring in situ in the ion source. This technique allows drect comparison of spectra before and after deuteration and the number of active hydrogens can be identified in most cases. The applicability of this method is demonstrated on different model compounds.

AB - We report here detailed studies of Bose et al.'s (J. Org. Chem. 47, 4008 (1982)) simple method for obtaining electron‐impact (EI) mass spectra from non‐volatile and/or thermolabile organic compounds by using ammonium salts. Good quality mass spectra can be obtained by mixing the analyte with different ammonium salts (mainly with NH4Cl) in a given ratio, the mixture being introduced through a conventonal direct probe. A wide variety of ammonium salts has been used to study the effect of the anion and to determine the optimum analyte:NH4X ratio and the other experimental parameters (i.e., electron energy, source temperature etc). A very simple and cheap means of determination of active hydrogen in hydroxyl, carboxyl, sulfhydryl, amino and amido etc groups by EI mass spectrometry using deuterated ammonium chloride (ND4CI) is described. The method is based on exchange of active hydrogen for deuterium occurring in situ in the ion source. This technique allows drect comparison of spectra before and after deuteration and the number of active hydrogens can be identified in most cases. The applicability of this method is demonstrated on different model compounds.

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