Detection of early precursors of t(12;21) positive pediatric acute lymphoblastic leukemia during follow-up

Renáta László, Donát Alpár, Béla Kajtár, Ágnes Lacza, Gábor Ottóffy, C. Kiss, Katalin Bartyik, K. Nagy, László Pajor

Research output: Article

2 Citations (Scopus)

Abstract

DNA-, RNA-, and cell-based methods provide different biologic information for determining the presence of minimal residual disease (MRD). We monitored the responses of patients with pediatric acute lymphoblastic leukemia (pALL) using DNA markers, TEL/AML1 expression, and scanning fluorescence microscopy (SFM). Using SFM, 36% of patients exhibited 1.5-3.1 log and 2.9-4.2 log higher MRD levels compared with those based on DNA and RNA markers, respectively. CD10+ ancestor cells with germline antigen receptors, but silent TEL/AML1 expression, may reside in the lymphoid stem cell compartment of treated t(12;21)-positive patients and might act as a potential source of cells for late relapses.

Original languageEnglish
Pages (from-to)158-160
Number of pages3
JournalPediatric Blood and Cancer
Volume54
Issue number1
DOIs
Publication statusPublished - jan. 2010

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Residual Neoplasm
Pediatrics
Genetic Markers
Fluorescence Microscopy
Lymphoid Progenitor Cells
RNA
Antigen Receptors
Recurrence
DNA

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Medicine(all)

Cite this

Detection of early precursors of t(12;21) positive pediatric acute lymphoblastic leukemia during follow-up. / László, Renáta; Alpár, Donát; Kajtár, Béla; Lacza, Ágnes; Ottóffy, Gábor; Kiss, C.; Bartyik, Katalin; Nagy, K.; Pajor, László.

In: Pediatric Blood and Cancer, Vol. 54, No. 1, 01.2010, p. 158-160.

Research output: Article

László, R, Alpár, D, Kajtár, B, Lacza, Á, Ottóffy, G, Kiss, C, Bartyik, K, Nagy, K & Pajor, L 2010, 'Detection of early precursors of t(12;21) positive pediatric acute lymphoblastic leukemia during follow-up', Pediatric Blood and Cancer, vol. 54, no. 1, pp. 158-160. https://doi.org/10.1002/pbc.22300
László, Renáta ; Alpár, Donát ; Kajtár, Béla ; Lacza, Ágnes ; Ottóffy, Gábor ; Kiss, C. ; Bartyik, Katalin ; Nagy, K. ; Pajor, László. / Detection of early precursors of t(12;21) positive pediatric acute lymphoblastic leukemia during follow-up. In: Pediatric Blood and Cancer. 2010 ; Vol. 54, No. 1. pp. 158-160.
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AU - Ottóffy, Gábor

AU - Kiss, C.

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