Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides

Azzurra Stefanucci, Ettore Novellino, Giorgia Macedonio, Marilisa Pia Dimmito, Sako Mirzaie, Fernanda Caldas Cardoso, Richard Lewis, Ferenc Zádor, A. Erdei, Szabolcs Dvorácskó, C. Tömböly, S. Benyhe, Stefano Pieretti, Paola Minosi, Adriano Mollica

Research output: Article

1 Citation (Scopus)

Abstract

In this paper we reported the synthesis and the in vitro and the in vivo biological evaluation of linear pseudo-peptides incorporating the N-VGCC blocker tripeptide Phe-NMe-Leu-Tyr(OBz)-NtBu and the biphalin pharmacophore Tyr-d-Ala-Gly-Phe. The novel sequences have been designed by using amino acids of different length to join the two pharmacophores and explore the structure-activity relationships of the novel compounds.

Original languageEnglish
Pages (from-to)5656-5659
Number of pages4
JournalNew Journal of Chemistry
Volume42
Issue number8
DOIs
Publication statusPublished - jan. 1 2018

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Opioid Analgesics
Peptides
Amino acids
Amino Acids
biphalin

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

Cite this

Stefanucci, A., Novellino, E., Macedonio, G., Dimmito, M. P., Mirzaie, S., Caldas Cardoso, F., ... Mollica, A. (2018). Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. New Journal of Chemistry, 42(8), 5656-5659. https://doi.org/10.1039/c7nj04969b

Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. / Stefanucci, Azzurra; Novellino, Ettore; Macedonio, Giorgia; Dimmito, Marilisa Pia; Mirzaie, Sako; Caldas Cardoso, Fernanda; Lewis, Richard; Zádor, Ferenc; Erdei, A.; Dvorácskó, Szabolcs; Tömböly, C.; Benyhe, S.; Pieretti, Stefano; Minosi, Paola; Mollica, Adriano.

In: New Journal of Chemistry, Vol. 42, No. 8, 01.01.2018, p. 5656-5659.

Research output: Article

Stefanucci, A, Novellino, E, Macedonio, G, Dimmito, MP, Mirzaie, S, Caldas Cardoso, F, Lewis, R, Zádor, F, Erdei, A, Dvorácskó, S, Tömböly, C, Benyhe, S, Pieretti, S, Minosi, P & Mollica, A 2018, 'Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides', New Journal of Chemistry, vol. 42, no. 8, pp. 5656-5659. https://doi.org/10.1039/c7nj04969b
Stefanucci A, Novellino E, Macedonio G, Dimmito MP, Mirzaie S, Caldas Cardoso F et al. Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. New Journal of Chemistry. 2018 jan. 1;42(8):5656-5659. https://doi.org/10.1039/c7nj04969b
Stefanucci, Azzurra ; Novellino, Ettore ; Macedonio, Giorgia ; Dimmito, Marilisa Pia ; Mirzaie, Sako ; Caldas Cardoso, Fernanda ; Lewis, Richard ; Zádor, Ferenc ; Erdei, A. ; Dvorácskó, Szabolcs ; Tömböly, C. ; Benyhe, S. ; Pieretti, Stefano ; Minosi, Paola ; Mollica, Adriano. / Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. In: New Journal of Chemistry. 2018 ; Vol. 42, No. 8. pp. 5656-5659.
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