Depression comorbidity in spinocerebellar ataxia

Tanja Schmitz-Hübsch, Mathieu Coudert, Sophie Tezenas du Montcel, Paola Giunti, Robyn Labrum, Alexandra Dürr, Pascale Ribai, Perrine Charles, Christoph Linnemann, Ludger Schöls, Maryla Rakowicz, Rafal Rola, Elszbieta Zdzienicka, Roberto Fancellu, Caterina Mariotti, L. Balikó, B. Melegh, Alessandro Filla, Elena Salvatore, Bart P C van de WarrenburgSandra Szymanski, Jon Infante, Dagmar Timmann, Sylvia Boesch, Chantal Depondt, Jun Suk Kang, Jörg B. Schulz, Thomas Klopstock, Nicole Lossnitzer, Bernd Löwe, Caroline Frick, Daniela Rottländer, Thomas E. Schlaepfer, Thomas Klockgether

Research output: Article

40 Citations (Scopus)

Abstract

This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.

Original languageEnglish
Pages (from-to)870-876
Number of pages7
JournalMovement Disorders
Volume26
Issue number5
DOIs
Publication statusPublished - ápr. 2011

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Spinocerebellar Ataxias
Comorbidity
Depression
Antidepressive Agents
Health
Psychiatry
Interviews
Major Depressive Disorder
Ataxia
Sleep
Multivariate Analysis
Surveys and Questionnaires

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Schmitz-Hübsch, T., Coudert, M., Tezenas du Montcel, S., Giunti, P., Labrum, R., Dürr, A., ... Klockgether, T. (2011). Depression comorbidity in spinocerebellar ataxia. Movement Disorders, 26(5), 870-876. https://doi.org/10.1002/mds.23698

Depression comorbidity in spinocerebellar ataxia. / Schmitz-Hübsch, Tanja; Coudert, Mathieu; Tezenas du Montcel, Sophie; Giunti, Paola; Labrum, Robyn; Dürr, Alexandra; Ribai, Pascale; Charles, Perrine; Linnemann, Christoph; Schöls, Ludger; Rakowicz, Maryla; Rola, Rafal; Zdzienicka, Elszbieta; Fancellu, Roberto; Mariotti, Caterina; Balikó, L.; Melegh, B.; Filla, Alessandro; Salvatore, Elena; van de Warrenburg, Bart P C; Szymanski, Sandra; Infante, Jon; Timmann, Dagmar; Boesch, Sylvia; Depondt, Chantal; Kang, Jun Suk; Schulz, Jörg B.; Klopstock, Thomas; Lossnitzer, Nicole; Löwe, Bernd; Frick, Caroline; Rottländer, Daniela; Schlaepfer, Thomas E.; Klockgether, Thomas.

In: Movement Disorders, Vol. 26, No. 5, 04.2011, p. 870-876.

Research output: Article

Schmitz-Hübsch, T, Coudert, M, Tezenas du Montcel, S, Giunti, P, Labrum, R, Dürr, A, Ribai, P, Charles, P, Linnemann, C, Schöls, L, Rakowicz, M, Rola, R, Zdzienicka, E, Fancellu, R, Mariotti, C, Balikó, L, Melegh, B, Filla, A, Salvatore, E, van de Warrenburg, BPC, Szymanski, S, Infante, J, Timmann, D, Boesch, S, Depondt, C, Kang, JS, Schulz, JB, Klopstock, T, Lossnitzer, N, Löwe, B, Frick, C, Rottländer, D, Schlaepfer, TE & Klockgether, T 2011, 'Depression comorbidity in spinocerebellar ataxia', Movement Disorders, vol. 26, no. 5, pp. 870-876. https://doi.org/10.1002/mds.23698
Schmitz-Hübsch T, Coudert M, Tezenas du Montcel S, Giunti P, Labrum R, Dürr A et al. Depression comorbidity in spinocerebellar ataxia. Movement Disorders. 2011 ápr.;26(5):870-876. https://doi.org/10.1002/mds.23698
Schmitz-Hübsch, Tanja ; Coudert, Mathieu ; Tezenas du Montcel, Sophie ; Giunti, Paola ; Labrum, Robyn ; Dürr, Alexandra ; Ribai, Pascale ; Charles, Perrine ; Linnemann, Christoph ; Schöls, Ludger ; Rakowicz, Maryla ; Rola, Rafal ; Zdzienicka, Elszbieta ; Fancellu, Roberto ; Mariotti, Caterina ; Balikó, L. ; Melegh, B. ; Filla, Alessandro ; Salvatore, Elena ; van de Warrenburg, Bart P C ; Szymanski, Sandra ; Infante, Jon ; Timmann, Dagmar ; Boesch, Sylvia ; Depondt, Chantal ; Kang, Jun Suk ; Schulz, Jörg B. ; Klopstock, Thomas ; Lossnitzer, Nicole ; Löwe, Bernd ; Frick, Caroline ; Rottländer, Daniela ; Schlaepfer, Thomas E. ; Klockgether, Thomas. / Depression comorbidity in spinocerebellar ataxia. In: Movement Disorders. 2011 ; Vol. 26, No. 5. pp. 870-876.
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AU - Giunti, Paola

AU - Labrum, Robyn

AU - Dürr, Alexandra

AU - Ribai, Pascale

AU - Charles, Perrine

AU - Linnemann, Christoph

AU - Schöls, Ludger

AU - Rakowicz, Maryla

AU - Rola, Rafal

AU - Zdzienicka, Elszbieta

AU - Fancellu, Roberto

AU - Mariotti, Caterina

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AU - Melegh, B.

AU - Filla, Alessandro

AU - Salvatore, Elena

AU - van de Warrenburg, Bart P C

AU - Szymanski, Sandra

AU - Infante, Jon

AU - Timmann, Dagmar

AU - Boesch, Sylvia

AU - Depondt, Chantal

AU - Kang, Jun Suk

AU - Schulz, Jörg B.

AU - Klopstock, Thomas

AU - Lossnitzer, Nicole

AU - Löwe, Bernd

AU - Frick, Caroline

AU - Rottländer, Daniela

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